Jizhen Zou

TL;DR: Whether LINE-1 methylation patterns were associated with neural tube development and the possible relations between DNA methylation and key maternal metabolites involved in folate-mediated one-carbon metabolism were determined and Hypomethylation of Line-1 and genomic DNA was associated with an increased risk of NTDs.

TL;DR: Global DNA hypomethylation in fetal brain tissue was associated with N TD-affected pregnancy and DNA methylation levels were correlated with NTD complexity.

TL;DR: The results suggest that miRNA dysregulation is possibly involved in the pathogenesis of anencephaly, and the target genes of these miRNAs in the human genome are mapped.

TL;DR: Evidence from the genome-wide CNV study suggests that genic CNVs, particularly ciliogenic CNVs are associated with NTDs and two ciliogenesis pathways, tight junction and protein kinase A signaling, are potential pathways involved in NTD pathogenesis.

TL;DR: Comparison of MGMT promoter methylation revealed that hypomethylation was associated with an increased risk for cephalic malformations, especially with female embryos (Adjusted Odds Ratio = 8.250), which underscores the role of stable promotermethylation in the DNA repair enzymes MGMT for proper embryogenesis.