Y
Yiping Shen
Researcher at Boston Children's Hospital
Publications - 297
Citations - 13132
Yiping Shen is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 48, co-authored 216 publications receiving 11503 citations. Previous affiliations of Yiping Shen include Fudan University & Harvard University.
Papers
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Journal ArticleDOI
Association between Microdeletion and Microduplication at 16p11.2 and Autism
Lauren A. Weiss,Yiping Shen,Joshua M. Korn,Joshua M. Korn,Dan E. Arking,David T. Miller,Ragnheidur Fossdal,Evald Saemundsen,Hreinn Stefansson,Todd Green,Todd Green,Orah S. Platt,Douglas M. Ruderfer,Douglas M. Ruderfer,Christopher A. Walsh,David Altshuler,David Altshuler,Aravinda Chakravarti,Aravinda Chakravarti,Rudolph E. Tanzi,Kari Stefansson,Susan L. Santangelo,James F. Gusella,James F. Gusella,Pamela Sklar,Pamela Sklar,Bai-Lin Wu,Mark J. Daly,Mark J. Daly +28 more
TL;DR: A novel, recurrent microdeletion and a reciprocal microduplication that carry substantial susceptibility to autism and appear to account for approximately 1% of cases are identified.
Journal ArticleDOI
Association between microdeletion and microduplication at 16p11.2 and autism
Lauren A. Weiss,Yiping Shen,Joshua M. Korn,Dan E. Arking,David T. Miller,Ragnheidur Fossdal,Evald Saemundsen,Hreinn Stefansson,Manuel A. R. Ferreira,Todd Green,Orah S. Piatt,Douglas M. Ruderfer,Christopher A. Walsh,David Altshuler,Aravinda Chakravarti,Rudolph E. Tanzi,Kari Stefansson,Susan L. Santangelo,James F. Gusella,Pamela Sklar,Bai-Lin Wu,Mark J. Daly +21 more
Journal ArticleDOI
Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
Hyung Goo Kim,Shotaro Kishikawa,Anne W. Higgins,Ihn Sik Seong,Diana J. Donovan,Yiping Shen,Eric Lally,Lauren A. Weiss,Lauren A. Weiss,Juliane Najm,Kerstin Kutsche,Maria Descartes,Lynn Holt,Stephen R. Braddock,Robin Troxell,Lee M. Kaplan,Fred R. Volkmar,Ami Klin,Katherine D. Tsatsanis,David J. Harris,Ilse Noens,David L. Pauls,Mark J. Daly,Mark J. Daly,Marcy E. MacDonald,Marcy E. MacDonald,Cynthia C. Morton,Cynthia C. Morton,Bradley J. Quade,James F. Gusella +29 more
TL;DR: A number of rare sequence variants in the coding region, including two missense changes in conserved residues of the alpha-neurexin 1 leader sequence and of an epidermal growth factor (EGF)-like domain, suggest that even subtle changes in NRXN1 might contribute to susceptibility to ASD.
Journal ArticleDOI
Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries
Michael E. Talkowski,Jill A. Rosenfeld,Ian Blumenthal,Vamsee Pillalamarri,Colby Chiang,Adrian Heilbut,Carl Ernst,Carrie Hanscom,Elizabeth J. Rossin,Elizabeth J. Rossin,Amelia M. Lindgren,Shahrin Pereira,Douglas M. Ruderfer,Douglas M. Ruderfer,Andrew Kirby,Andrew Kirby,Stephan Ripke,Stephan Ripke,David J. Harris,Ji Hyun Lee,Kyungsoo Ha,Hyung Goo Kim,Benjamin D. Solomon,Andrea L. Gropman,Andrea L. Gropman,Diane Lucente,Katherine B. Sims,Toshiro K. Ohsumi,Mark L. Borowsky,Stephanie Loranger,Bradley J. Quade,Kasper Lage,Judith H. Miles,Bai-Lin Wu,Bai-Lin Wu,Bai-Lin Wu,Yiping Shen,Benjamin M. Neale,Benjamin M. Neale,Lisa G. Shaffer,Mark J. Daly,Cynthia C. Morton,Cynthia C. Morton,Cynthia C. Morton,James F. Gusella +44 more
TL;DR: The findings suggest a polygenic risk model of autism and reveal that some neurodevelopmental genes are sensitive to perturbation by multiple mutational mechanisms, leading to variable phenotypic outcomes that manifest at different life stages.
Journal ArticleDOI
Induced Pluripotent Stem Cells from Patients with Huntington’s Disease : Show CAG Repeat-Expansion-Associated Phenotypes
Virginia B. Mattis,Soshana P. Svendsen,Allison D. Ebert,Clive N. Svendsen,Alvin R. King,Malcolm Casale,Sara T. Winokur,Gayani Batugedara,Marquis P. Vawter,Peter J. Donovan,Leslie F. Lock,Leslie M. Thompson,Yu Zhu,Elisa Fossale,Ranjit Singh Atwal,Tammy Gillis,Jayalakshmi S. Mysore,Jian Hong Li,Ihn Sik Seong,Yiping Shen,Xiaoli Chen,Vanessa C. Wheeler,Marcy E. MacDonald,James F. Gusella,Sergey S Akimov,Nicolas Arbez,Tarja A. Juopperi,Tamara Ratovitski,Jason H. Chiang,Woon Roung Kim,Eka Chighladze,Erin Watkin,Chun Zhong,Georgia Makri,Robert N. Cole,Russell L. Margolis,Hongjun Song,Guo Li Ming,Christopher A. Ross,Julia A. Kaye,Julia A. Kaye,Aaron C. Daub,Aaron C. Daub,Punita Sharma,Punita Sharma,Amanda R. Mason,Amanda R. Mason,Steven Finkbeiner,Steven Finkbeiner,Junying Yu,James A. Thomson,David Rushton,Stephen P. Brazier,Alysia Battersby,Amanda Redfern,Hsui Er Tseng,Alexander William John Harrison,Paul J. Kemp,Nicholas D. Allen,Marco Onorati,Valentina Castiglioni,Elena Cattaneo,Jamshid Arjomand +62 more
TL;DR: The generation and characterization of 14 induced pluripotent stem cell (iPSC) lines from HD patients and controls reveal CAG-repeat-expansion-associated gene expression patterns that distinguish patient lines from controls, and early onset versus late onset HD.