Showing papers by "Joan Francesc Barquinero published in 2006"
TL;DR: The results support that the percentage of incomplete chromosome aberrations depends on radiation type; low-linear energy transfer (LET) radiation would produces less incomplete aberration than high-LET radiation.
Abstract: Purpose: To evaluate the types of induced chromosome aberrations after the exposure of peripheral blood to γ-rays by the simultaneous detection of all centromeres and telomeres; and to analyse the suitability of different radiation fingerprints for the assessment of radiation quality in cases of recent exposures.Material and methods: Peripheral blood samples were irradiated at 2, 4 and 6 Gy of γ-rays. Cytogenetic analysis was carried out by fluorescence in situ hybridization (FISH) technique with pan-centromeric and peptide nucleic acid (PNA)-telomeric DNA probes. Cells were analysed using a Cytovision® FISH workstation, chromosome aberrations and the length of the acentric fragments were recorded.Results: The total number of the incomplete chromosome elements was 276. The ratio between incomplete elements and multicentrics was 0.38. The number of acentrics was 1096, 71% were complete acentrics, 15% incomplete acentrics, and 14% interstitial fragments. The relative length of complete, incomplete and inter...
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