Showing papers by "Joana Carvalho published in 2013"
TL;DR: CDH1 somatic alterations exist in all clinical settings and histotypes of GC and associate with different survival rates, and their screening at GC diagnosis may predict patient prognosis and is likely to improve management of patients with this disease.
Abstract: Purpose The prognosis of gastric cancer (GC) is poor, and the molecular pathogenesis players are vastly unknown. Surgery remains the primary option in GC treatment. The aim of this study was to investigate the impact of somatic CDH1 alterations in prognosis and survival of patients with GC. Patients and Methods A series of patients with sporadic and familial GC (diffuse and intestinal; n = 246) were analyzed for somatic CDH1 mutations, promoter hypermethylation, and loss of heterozygosity (LOH) by polymerase chain reaction sequencing. E-cadherin protein expression was determined by immunohistochemistry. Associations between molecular, clinicopathologic, and survival data were analyzed. Results CDH1 somatic alterations were found in approximately 30% of all patients with GC. Both histologic types of sporadic GC displayed LOH in 7.5%, mutations in 1.7%, and hypermethylation in 18.4% of patients. Primary tumors from hereditary diffuse GC, lacking germline CDH1 alterations, showed exclusively CDH1 promoter hy...
158 citations
TL;DR: The combined impact protocol reduces inflammation and increases BMD, balance, and lower-extremity muscle strength, despite having little effect on bone metabolism markers, which reinforces the role of exercise to counteract the age-related inflammation, and the muscle strength and BMD reduction.
58 citations
TL;DR: Aerobic training was demonstrated to reduce hs-CRP and blood pressure in community-dwelling elderly participants with no serious medical conditions and provides further evidence for the benefits of aerobic and resistance training on reducing body fat.
57 citations
TL;DR: Results indicated that students reporting sexual aggression against women presented significantly more erectile and orgasmic difficulties, and more sexual inhibition due to the threat of performance failure than the control peers.
23 citations
TL;DR: In the EG, the results from the Pedal Dexterity test showed that both males and females from the RCH and DLC improved their performances after the MEP, and in the CG, no significant effects or interactions were found for any of the context groups.
Abstract: This study investigated the effects of a multimodal exercise program (MEP) on pedal dexterity and balance in two groups of older adult participants (65–92 years of age) from a psychiatric hospital center (HC), a residential care home (RCH), and a daily living center (DLC). The experimental group (EG) trained three times per week for 12 months, and the control group (CG) maintained their normal activities. The Mini-Mental State Examination and the Modified Baecke Questionnaire, as well as the Pedal Dexterity and the Tinetti tests, were applied to all subjects before and after the experimental protocol. Furthermore, the foot preference was controlled using the Lateral Preference Questionnaire proposed by Coren [10]. In the EG, the results from the Pedal Dexterity test showed that both males and females from the RCH and DLC improved their performances after the MEP. In the HC, the males slightly decreased their performance with both feet, contrarily to females. Both males and females from the CG decreased their pedal dexterity performance, namely, with the non-preferred foot. Concerning the Tinetti test, the EG of both males and females from the HC, the RCH (males were better than females regarding the gender factor), and the DLC improved their balance after the MEP. In the CG, no significant effects or interactions were found for any of the context groups.
3 citations
DOI•
27 Mar 2013TL;DR: In this paper, a pratica de atividade fisica assume uma importância primordial ao surgir como uma oportunidade para reconquistarem um corpo mais agil e mais jovem.
Abstract: Este estudo objetivou conhecer as percepcoes de pessoas idosas sobre a definicao de genero, seus papeis sociais e a importância da sexualidade na construcao da identidade de genero, assim como teve o intuito de analisar as expectativas relacionadas com o corpo relativamente a participacao num programa de atividade fisica (PAF). A amostra e constituida por trinta pessoas (16 homens e 15 mulheres), com uma media de idade de 63,4 ± 4,8 anos, inscritas pela primeira vez num PAF que decorreu num municipio da regiao Norte de Portugal (V. N. de Famalicao). Foram realizadas entrevistas semiestruturadas que posteriormente foram transcritas e formatadas para tratamento da informacao no programa QSRNVivo7. Apos a analise dos dados, constatamos que os participantes apresentam leituras renovadas sobre a masculinidade e a feminilidade, sobre a sua identidade corporal e as suas vivencias sexuais. A pratica de atividade fisica assume uma importância primordial ao surgir como uma oportunidade para reconquistarem um corpo mais agil e mais jovem.
2 citations
01 Jan 2013
2 citations
TL;DR: Atencao (AT) and Velocidade Perceptiva (FI) as discussed by the authors were evaluated in a pesquisa of 54 idosos do sexo feminino residentes na Cidade do Porto and pertencentes ao Centro de Investigacao em Atividade Fisica, Esporte e Lazer (CIAFEL).
Abstract: O Presente estudo teve como objetivo avaliar a Atencao (AT) e Velocidade Perceptiva (FI) numa populacao idosa, praticante e nao praticante de atividade fisica. Foram sujeitos da pesquisa 54 idosos do sexo feminino residentes na Cidade do Porto e pertencentes ao Centro de Investigacao em Atividade Fisica, Esporte e Lazer (CIAFEL) da Faculdade de Desporto da Universidade do Porto. Os instrumentos para mensuracao dos dados foram: os testes de Atencao Toulouse-Pieron (1982) e Figuras Identicas de Thurstone (1998) para afericao da velocidade perceptiva.
1 citations