R
Raquel Seruca
Researcher at University of Porto
Publications - 280
Citations - 20167
Raquel Seruca is an academic researcher from University of Porto. The author has contributed to research in topics: Cancer & Hereditary diffuse gastric cancer. The author has an hindex of 72, co-authored 274 publications receiving 18552 citations. Previous affiliations of Raquel Seruca include Institute of Molecular Pathology and Immunology of the University of Porto.
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Journal ArticleDOI
BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC
Paula Soares,Vítor Trovisco,Ana Rocha,Jorge Lima,Patrícia Castro,Ana Preto,Valdemar Máximo,Tiago Botelho,Raquel Seruca,Manuel Sobrinho-Simões +9 more
TL;DR: The results suggest that BRAFV599E mutation is frequent in the etiopathogenesis of PTC, and appears to be an alternative event to RET/PTC rearrangement rather than to RAS mutations, which are rare in PTC.
Journal ArticleDOI
Helicobacter pylori and Interleukin 1 Genotyping: An Opportunity to Identify High-Risk Individuals for Gastric Carcinoma
Ceu Figueiredo,José Carlos Machado,Paul D.P. Pharoah,Raquel Seruca,Sónia Sousa,Ralph Carvalho,Ana Filipa Capelinha,Wim Quint,Carlos Caldas,Leen-Jan van Doorn,Fátima Carneiro,Manuel Sobrinho-Simões +11 more
TL;DR: Combined bacterial/host genotyping may provide an important tool in defining disease risk and targeting H. pylori eradication to high-risk individuals.
Journal Article
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.
Päivi Peltomäki,Ragnhild A. Lothe,Lauri A. Aaltonen,Lea Pylkkänen,Minna Nyström-Lahti,Raquel Seruca,Leonor David,Ruth Holm,David Ryberg,Aage Haugen +9 more
TL;DR: The findings suggest that the cancers belonging to the hereditary non-polyposis colorectal carcinoma tumor spectrum may have essential pathogenetic steps in common, including a tendency to multiple replication errors.
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Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR.
Nirosha Suraweera,Alex Duval,Maryline Reperant,Christelle Vaury,Daniela Furlan,Karen Leroy,Raquel Seruca,Barry Iacopetta,Richard Hamelin +8 more
TL;DR: It is proposed that using a pentaplex polymerase chain reaction system allows accurate evaluation of tumor MSI status of DNA with 100% sensitivity and specificity without the need to match normal DNA.
Journal ArticleDOI
A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
José Carlos Machado,Ceu Figueiredo,Paulo Canedo,Paul D.P. Pharoah,Ralph Carvalho,Sérgio Nabais,Catarina Castro Alves,Maria Luisa Campos,Leen-Jan van Doorn,Carlos Caldas,Raquel Seruca,Fátima Carneiro,Manuel Sobrinho-Simões +12 more
TL;DR: Findings show that a proinflammatory polymorphism in the TNF-alpha gene is associated with increased risk for GC, and that it is possible to define a specific genetic profile associated with highest risk for CAG and GC.