Joanne Berger-Sweeney

TL;DR: The data suggest that the cholinergic cortical system is critical to the performance of this spatial memory task, and an unambiguous interpretation of the anatomical locus of behavioral deficits was not possible because of damage to cholinery striatal interneurons (nBM group) and to noncholinergic cerebellar Purkinje cells (ventricular group).

TL;DR: Results suggest that aged mice exhibit significant deficits in spatial and olfactory reference memory relative to young mice, whereas middle-aged mice exhibit only a moderate spatial memory deficit and spatial reference memory decline begins at an earlier age in females than in males, a finding that may be related to the cessation of estrous cycling.

TL;DR: Reduced expression of GlyT1 enhances hippocampal NMDAR function and memory retention and protects against an amphetamine disruption of sensory gating, suggesting that drugs which inhibit GlyT 1 might have both cognitive enhancing and antipsychotic effects.

TL;DR: This review examines some of the most extensively-studied animal models of disrupted stages of cortical development and compares long-term anatomical, neurochemical, and behavior abnormalities in these models and discusses how these developmental studies provide insights into cellular and neurochemical correlates of behavioral functional abnormalities.

TL;DR: This study provides the first evidence that the abnormal motor and cognitive behavioral phenotype in Mecp2 mice is consistent with specific volume reductions in brain regions associated with these behaviors, and shows how these data parallel the human condition.