J
Joanne M. Smallheer
Researcher at Bristol-Myers Squibb
Publications - 46
Citations - 1166
Joanne M. Smallheer is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Factor IXa & Thrombin. The author has an hindex of 19, co-authored 46 publications receiving 1109 citations.
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Five-membered heterocycles useful as serine protease inhibitors
Jon J. Hangeland,Mimi L. Quan,Joanne M. Smallheer,Gregory S. Bisacchi,James R. Corte,Todd J. Friends,Zhong Sun,Karen A. Rossi,Cullen L. Cavallaro +8 more
TL;DR: In this article, the authors provided compounds of Formula (I) or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, X1, X2, X3, X4, and X5 are as defined herein.
Journal ArticleDOI
Factor Xa inhibitors: next-generation antithrombotic agents
Journal ArticleDOI
Microbial products. VIII. Azinothricin, a novel hexadepsipeptide antibiotic.
Hubert Maehr,Chao-Min Liu,Norberto J. Palleroni,Joanne M. Smallheer,Louis J. Todaro,Thomas H. Williams,John F. Blount +6 more
TL;DR: Azinothricin was isolated from the culture filtrate of Streptomyces sp.
Journal ArticleDOI
Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors.
Mimi L. Quan,Pancras C. Wong,Cailan Wang,Francis J. Woerner,Joanne M. Smallheer,Frank A. Barbera,Jeffrey M. Bozarth,Randi L. Brown,Mark R. Harpel,Joseph M. Luettgen,Paul E. Morin,Tara L. Peterson,Vidhyashankar Ramamurthy,Alan R. Rendina,Karen A. Rossi,Carol A. Watson,Anzhi Wei,Ge Zhang,Dietmar A. Seiffert,Ruth R. Wexler +19 more
TL;DR: A series of tetrahydroquinoline (THQ) derivatives as FXIa inhibitors exhibited excellent antithrombotic efficacy in rabbit thrombosis models and did not prolong bleeding times, demonstrating proof of concept for theFXIa mechanism in animal models with a reversible, small molecule inhibitor.