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Dietmar A. Seiffert
Researcher at Bristol-Myers Squibb
Publications - 88
Citations - 2470
Dietmar A. Seiffert is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 24, co-authored 77 publications receiving 1926 citations. Previous affiliations of Dietmar A. Seiffert include Duke University & DuPont.
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Journal ArticleDOI
Effects of factor IX or factor XI deficiency on ferric chloride‐induced carotid artery occlusion in mice
Xinkang Wang,Qiufang Cheng,Lin Xu,Giora Z. Feuerstein,Mei-Yin Hsu,Patricia L. Smith,Dietmar A. Seiffert,William A. Schumacher,Martin L. Ogletree,David Gailani +9 more
TL;DR: While FXI and FIX deficiencies were indistinguishable in the carotid artery injury model, there was a marked difference in a tail‐bleeding‐time assay, suggesting therapeutic inhibition of FXI may be a reasonable strategy for treating or preventing thrombus formation.
Journal ArticleDOI
Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction: Detailed Phenotypes, Prognosis, and Response to Spironolactone.
Jordana B. Cohen,Sarah J. Schrauben,Lei Zhao,Michael Basso,Mary Ellen Cvijic,Zhuyin Li,Melissa Yarde,Zhaoqing Wang,Priyanka Bhattacharya,Diana A. Chirinos,Stuart B. Prenner,Payman Zamani,Dietmar A. Seiffert,Bruce D. Car,David A. Gordon,Kenneth B. Margulies,Thomas P. Cappola,Julio A. Chirinos,Julio A. Chirinos +18 more
TL;DR: Important differences in circulating biomarkers, cardiac/arterial characteristics, prognosis, and response to spironolactone across clinical HFpEF phenogroups are identified.
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Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion.
Jacob Schneiderman,Gerald M. Bordin,Isaac Engelberg,Raphael Adar,Dietmar A. Seiffert,Therese C. Thinnes,Eugene F. Bernstein,Ralph B. Dilley,David J. Loskutoff +8 more
TL;DR: The increased fibrinolytic capacity in AAA wall may promote angiogenesis and contribute to local proteolytic degradation of the aortic wall leading to physical weakening and active expansion of the aneurysm.
Journal ArticleDOI
Effects of factor XI deficiency on ferric chloride-induced vena cava thrombosis in mice.
Xinkang Wang,Patricia L. Smith,Mei-Yin Hsu,David Gailani,William A. Schumacher,Martin L. Ogletree,Dietmar A. Seiffert +6 more
TL;DR: Enhanced clot lysis was demonstrated in FXI‐deficient mouse and human plasma compared to those supplemented with FXIa and therapeutic inhibition of FXI may be a reasonable therapeutic strategy to treat or prevent venous thrombosis.
Journal ArticleDOI
Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding
Pancras C. Wong,Dietmar A. Seiffert,J.Eileen Bird,Carol A. Watson,Jeffrey S. Bostwick,Mary Giancarli,Nick J. Allegretto,Ji Hua,David G. Harden,Jocelyne Guay,Mario Callejo,Michael M. Miller,R. Michael Lawrence,Jacques Banville,Julia Guy,Brad D. Maxwell,E. Scott Priestley,Anne Marinier,Ruth R. Wexler,Michel Bouvier,David A. Gordon,William A. Schumacher,Jing Yang +22 more
TL;DR: Targeting PAR4 is an attractive antiplatelet strategy with the potential to treat patients at a high risk of atherothrombosis with superior safety compared with the current standard of care, and is defined as a biological role of PAR4 in mediating platelet aggregation.