J
João Ramalho-Santos
Researcher at University of Coimbra
Publications - 182
Citations - 10325
João Ramalho-Santos is an academic researcher from University of Coimbra. The author has contributed to research in topics: Sperm & Mitochondrion. The author has an hindex of 45, co-authored 166 publications receiving 9338 citations. Previous affiliations of João Ramalho-Santos include University of Washington & University of Groningen.
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Journal ArticleDOI
Energy metabolism in human pluripotent stem cells and their differentiated counterparts.
Sandra Varum,Ana S. B. Rodrigues,Michelle Barbi de Moura,Olga Momčilović,Charles A. Easley,João Ramalho-Santos,Bennett Van Houten,Gerald Schatten +7 more
TL;DR: The results demonstrate that, although the metabolic signature of IPSCs is not identical to that of hESCs, nonetheless they cluster with h ESCs rather than with their somatic counterparts, revealing that human pluripotent cells rely mostly on glycolysis to meet their energy demands.
Journal ArticleDOI
Ubiquitin tag for sperm mitochondria
Peter Sutovsky,Ricardo D. Moreno,João Ramalho-Santos,Tanja Dominko,Calvin Simerly,Gerald Schatten +5 more
TL;DR: It is shown here that sperm mitochondria inside fertilized cow and monkey eggs are tagged by the recycling marker protein ubiquitin, which is a death sentence that is written during spermatogenesis and executed after the sperm mitochondira encounter the egg's cytoplasmic destruction machinery.
Journal ArticleDOI
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
Alexandre Gaspar-Maia,Adi Alajem,Fanny Polesso,Rupa Sridharan,Michael Mason,Amy Heidersbach,João Ramalho-Santos,Michael T. McManus,Kathrin Plath,Eran Meshorer,Miguel Ramalho-Santos +10 more
TL;DR: The results indicate that Chd1 is essential for open chromatin and pluripotency of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state.
Journal ArticleDOI
Ubiquitinated Sperm Mitochondria, Selective Proteolysis, and the Regulation of Mitochondrial Inheritance in Mammalian Embryos
Peter Sutovsky,Ricardo D. Moreno,João Ramalho-Santos,Tanja Dominko,Calvin Simerly,Gerald Schatten +5 more
TL;DR: It is shown that the proteolytic destruction of bull sperm mitochondria inside cow egg cytoplasm depends upon the activity of the universal proteolysis marker, ubiquitin, and the lysosomal apparatus of the egg.