Protic Ionic Liquids: Properties and Applications

Ionic liquids in catalysis

A comprehensive database on physical properties of ionic liquids (ILs), which was collected from 109 kinds of literature sources in the period from 1984 through 2004, has been presented. There are 1680 pieces of data on the physical properties for 588 available ILs, from which 276 kinds of cations and 55 kinds of anions were extracted. In terms of the collected database, the structure-property relationship was evaluated. The correlation of melting points of two most common systems, disubstituted imidazolium tetrafluoroborate and disubstituted imidazolium hexafluorophosphate, was carried out using a quantitative structure-property relationship method.

Physical Properties of Ionic Liquids: Database and Evaluation

Ionic liquids are remarkable chemical compounds, which find applications in many areas of modern science. Because of their highly tunable nature and exceptional properties, ionic liquids have become essential players in the fields of synthesis and catalysis, extraction, electrochemistry, analytics, biotechnology, etc. Apart from physical and chemical features of ionic liquids, their high biological activity has been attracting significant attention from biochemists, ecologists, and medical scientists. This Review is dedicated to biological activities of ionic liquids, with a special emphasis on their potential employment in pharmaceutics and medicine. The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems. Dedicated attention is given to a novel active pharmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in ...

Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine.

Ionic liquids: solvent properties and organic reactivity

This review deals with recent advances in the investigation of ionic liquids (ILs) in the field of chirality, i.e. asymmetric synthesis and new chiral solvents.

Ionic liquids and chirality: opportunities and challenges

Chiral ionic solvents were almost unexplored before the last five years. This field which is of increasing importance could constitute a renewal for the chemistry of chiral solvents. So far reported examples are designed either from the chiral pool (aminoacids, hydroxyacids, amines, aminoalcohols, terpenes and alkaloids) or by asymmetric synthesis; they can bear central, axial or planar chirality. Modern applications in asymmetric synthesis, enzymatic chemistry, chiral chromatography and NMR are surveyed. Their use in the field of liquid crystals and for stereoselective polymerisation are also discussed. At the end of the article, a series of tables is compiled including all the CILs described to date and their physical properties.

Chiral ionic liquids, a renewal for the chemistry of chiral solvents? Design, synthesis and applications for chiral recognition and asymmetric synthesis

CNRS-UMR 5068, LSPCMIB, Universite Paul Sabatier, 118 route de Narbonne, F-31062 Toulouse Cedex 9, France, Laboratoire de Chimie Moleculaire et Thio-organique, ENSICAEN, Universite de Caen Basse-Normandie, FR CNRS 3038, 6 boulevard du Marechal Juin, F-14050 Caen, France, CNRS-UMR 6014, IRCOF, Universite de Rouen, rue Tesniere, F-76821 Mont-Saint-Aignan Cedex, France, and URCOM, EA 3221 FR CNRS 3038, Universite du Havre, 25 rue Ph. Lebon, BP 540, F-76058 Le Havre Cedex, France

Ionic Liquids: New Targets and Media for α-Amino Acid and Peptide Chemistry

Heterocyclic compounds are of outstanding importance as pharmaceuticals, agrochemicals, fine and bulk chemicals, and ligands for catalysis.1 Among the different heterocycles, 2-oxazolines have been widely studied and reviewed,2 especially chiral oxazolines3 and bis(oxazolines),4 due to their wide application as ligands for asymmetric catalysis. Compared to 2-oxazolines, the sulfur analogues, that is, the 2-thiazolines, have received less attention. To the best of our knowledge, there is only one review, published by Fustero et al. in 2001,5 which focuses on the preparation and to some extent synthetic applications of both 2-alkyl2-thiazolines and 2-alkyl-2-oxazolines. Recently, various groups have paid attention to the chemical properties of 2-thiazolines, mainly because of the unique properties of sulfur. In different reports, a reactivity that often dramatically differs from that of the corresponding oxazoline derivatives was pointed out. In this contribution, we wish to give an overview of the chemistry of 2-thiazolines, including new methodologies for their preparation, and recent applications, such as their growing use in organic synthesis in the biological field and asymmetric catalysis as ligands. The methods enabling access to thiazolines will first be underlined. Then the reactivity and applications in the fields of organic synthesis, biomolecules (natural or not), and catalysis will be documented. The structure of the thiazolines treated in this review is illustrated in Figure 1. Compounds bearing atoms other than carbon at the 2-position, including 2-H-thiazolines, 2-aminothiazolines, or 2-halogenothiazolines, are beyond the scope of this review. Cited references are restricted to journals, reviews, and books. Literature coverage for this review extends up to September 2007.

Jocelyne Levillain

Papers

Ionic liquids and chirality: opportunities and challenges

Chiral ionic liquids, a renewal for the chemistry of chiral solvents? Design, synthesis and applications for chiral recognition and asymmetric synthesis

Ionic Liquids: New Targets and Media for α-Amino Acid and Peptide Chemistry

Overview of the chemistry of 2-thiazolines.

Synthesis and properties of thiazoline based ionic liquids derived from the chiral pool