J
Jochen Steppan
Researcher at Johns Hopkins University
Publications - 84
Citations - 2980
Jochen Steppan is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pulse wave velocity & Medicine. The author has an hindex of 23, co-authored 77 publications receiving 2513 citations. Previous affiliations of Jochen Steppan include Johns Hopkins University School of Medicine & Heidelberg University.
Papers
More filters
Journal ArticleDOI
Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels
Asif K. Mustafa,Gautam Sikka,Sadia K. Gazi,Jochen Steppan,Sung M. Jung,Anil K. Bhunia,Viachaslau Barodka,Farah K. Gazi,Roxanne K. Barrow,Rui Wang,L. Mario Amzel,Dan E. Berkowitz,Solomon H. Snyder +12 more
TL;DR: H2S is a major EDHF that causes vascular endothelial and smooth muscle cell hyperpolarization and vasorelaxation by activating the ATP-sensitive, intermediate conductance and small conductance potassium channels through cysteine S-sulfhydration.
Journal ArticleDOI
Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41
Niranjana Natarajan,Daijiro Hori,Sheila Flavahan,Jochen Steppan,Nicholas A. Flavahan,Dan E. Berkowitz,Jennifer L. Pluznick +6 more
TL;DR: These studies suggest that endothelial Gpr41 lowers baseline BP, likely by decreasing active vascular tone without altering passive characteristics of the blood vessels, and that GPR41 KO mice have hypertension of a vascular origin.
Journal ArticleDOI
Sepsis and major abdominal surgery lead to flaking of the endothelial glycocalix.
Jochen Steppan,Stefan Hofer,Benjamin Funke,Thorsten Brenner,Michael Henrich,Eike Martin,Jürgen Weitz,Ursula Hofmann,Markus A. Weigand +8 more
TL;DR: High levels of glycocalIX markers indicated that significant flaking of the endothelial glycocalix occurred in patients with sepsis, and to a lesser extent in patients after major abdominal surgery, which could explain the nonspecific capillary leaking syndrome of patients withSepsis and after major abdomen surgery.
Journal ArticleDOI
Knockdown of arginase I restores NO signaling in the vasculature of old rats.
Anthony R. White,Sungwoo Ryoo,Dechun Li,Hunter C. Champion,Jochen Steppan,Danming Wang,Daniel Nyhan,Artin A. Shoukas,Joshua M. Hare,Dan E. Berkowitz +9 more
TL;DR: The hypothesis that Arg I plays a critical role in the pathobiology of age-related vascular endothelial dysfunction is supported and antisense (AS) oligonucleotides may, therefore, represent a novel therapeutic strategy against age- related vascular endothelium dysfunction.
Journal ArticleDOI
Vascular Stiffness and Increased Pulse Pressure in the Aging Cardiovascular System
TL;DR: The effects of age-associated increased vascular stiffness on systolic blood pressure, pulse pressure, augmentation index, and cardiac workload are reviewed and pulse wave velocity is described as a method to measure vascular stiffness.