J
Joël Cotton
Researcher at National and Kapodistrian University of Athens
Publications - 7
Citations - 584
Joël Cotton is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Angiotensin-converting enzyme & ACE inhibitor. The author has an hindex of 7, co-authored 7 publications receiving 544 citations. Previous affiliations of Joël Cotton include French Alternative Energies and Atomic Energy Commission.
Papers
More filters
Journal ArticleDOI
RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites
Vincent Dive,Joël Cotton,Athanasios Yiotakis,Annie Michaud,Stamatia Vassiliou,Jiri Jiracek,Gilles Vazeux,Marie-Thérèse Chauvet,Philippe Cuniasse,Pierre Corvol +9 more
TL;DR: RXP 407, a highly potent and selective inhibitor of the N-terminal active site of wild ACE, may lead to a new generation of ACE inhibitors able to block in vivo only a subset of the different functions regulated by ACE.
Journal ArticleDOI
Roles of the Two Active Sites of Somatic Angiotensin-Converting Enzyme in the Cleavage of Angiotensin I and Bradykinin Insights From Selective Inhibitors
Dimitris Georgiadis,Fabrice Beau,Bertrand Czarny,Joël Cotton,Athanasios Yiotakis,Vincent Dive +5 more
TL;DR: In vivo the conversion of Ang I seems to involve the two active sites of ACE, free of inhibitor, and it might be suggested that the gene duplication of ACE in vertebrates may represent a means for regulating the cleavage of angiotensin I differently from that of BK.
Journal Article
RXP 407, a Selective Inhibitor of the N-Domain of Angiotensin I-Converting Enzyme, Blocks in Vivo the Degradation of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro with No Effect on Angiotensin I Hydrolysis
Christophe Junot,Marie-Françoise Gonzales,Eric Ezan,Joël Cotton,Gilles Vazeux,Annie Michaud,Michel Azizi,Stamatia Vassiliou,Athanasios Yiotakis,Pierre Corvol,Vincent Dive +10 more
TL;DR: RXP 407 is the first ACE inhibitor that might be used to control selectively AcSDKP metabolism with no effect on blood pressure regulation.
Journal ArticleDOI
Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme.
David Coates,R. Elwyn Isaac,Joël Cotton,Richard J. Siviter,Tracy Ann Williams,Alan D. Shirras,Pierre Corvol,Vincent Dive +7 more
TL;DR: The relationship of Ance and Acer to the N- and C-domains of human sACE is investigated by genomic sequence analysis and by using domain-selective inhibitors, including RXP 407, a selective inhibitor of the human N-domain.
Journal ArticleDOI
Structural determinants of RXPA380, a potent and highly selective inhibitor of the angiotensin-converting enzyme C-domain.
TL;DR: Structural insights provided by this study should enhance understanding of the factors controlling the selectivity of the two domains of somatic ACE and allow the design of new selective ACE inhibitors.