Johan Van hemel

TL;DR: It is reported that the antimalarial drug artemisinin inhibits hepatitis C virus (HCV) replicon replication in a dose-dependent manner in two replicon constructs at concentrations that have no effect on the proliferation of the exponentially growing host cells.

TL;DR: Two new cyclic lipodepsipeptides named pseudodesmins A and B have been isolated from Pseudomonas bacteria collected from the mucus layer in the skin of the black belly salamander and show moderate antibacterial activity against Gram positive bacteria, including MRSA.

TL;DR: Subtilis strain PB6, provided as a preparation of spores, shows pre-clinical anti-inflammatory effects, suggesting further evaluation in a clinical intervention trial, e.g. with IBD type patients.

TL;DR: An efficient convergent approach has been developed for the construction of novel, non-natural, carbohydrate-based macrolides and the obtained macrolide analogues have been screened for biological activity against gram-positive and gram-negative bacteria, including resistant strains, yeasts, and molds.

TL;DR: An efficient convergent approach has been developed for the construction of novel, nonnatural polysubstituted carbohydrate-based macrolides through the formation of the macrocyclic ring via a ring-closing metathesis reaction.