Johanna K. DiStefano

TL;DR: A role for hepatic miRNAs in the pathogenesis of NAFLD-related fibrosis is supported and possible new insight is yielded into the molecular mechanisms underlying the initiation and progression of liver fibrosis and cirrhosis.

TL;DR: The role of lncRNAs in the pathogenesis of type 2 diabetes mellitus and related complications has only recently been recognized, but there is already evidence for their involvement in many of the pathophysiological mechanisms underlying the disease.

TL;DR: This commonly used technique to genotype a moderate number of markers in this kind of study is introduced and described and protocols that can be directly used in laboratories aiming to perform moderate- to large-scale genotyping studies are included.

TL;DR: This review summarizes select lncRNAs that have been shown to wield functional relevance in the initiation, progression, or metastasis of HCC, focusing on the specific mechanisms by which lncRNA effects might be linked to clinical manifestations of the disease.

TL;DR: Se sequencing-based mRNA profiling analysis of liver samples from individuals with normal histology found evidence for differential levels of 3820 and 2980 transcripts in lobular inflammation and advanced fibrosis, respectively, compared withnormal histology, including 176 genes specific to fibrosis.