J
John Farrell
Researcher at University of Liverpool
Publications - 60
Citations - 2718
John Farrell is an academic researcher from University of Liverpool. The author has contributed to research in topics: Antigen & CD8. The author has an hindex of 26, co-authored 57 publications receiving 2412 citations. Previous affiliations of John Farrell include Royal Liverpool and Broadgreen University Hospital NHS Trust.
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Journal ArticleDOI
Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.
Dean J. Naisbitt,Markus Britschgi,G. Wong,John Farrell,Jan P.H. Depta,David Chadwick,Werner J. Pichler,Munir Pirmohamed,Brian Kevin Park +8 more
TL;DR: Drug-specific T cells in CBZ-hypersensitive patients that are phenotypically different from T cells involved in other serious cutaneous adverse drug reactions are characterized.
Journal ArticleDOI
Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury
Manal Monshi,Lee Faulkner,Andrew Gibson,Rosalind E. Jenkins,John Farrell,Caroline Earnshaw,Ana Alfirevic,Karin Cederbrant,Ann K. Daly,Neil French,Munir Pirmohamed,B. Kevin Park,Dean J. Naisbitt +12 more
TL;DR: This work defines the immune basis for flucloxacillin‐induced liver injury and links the genetic association to the iatrogenic disease.
Journal ArticleDOI
Characterization of drug-specific T cells in lamotrigine hypersensitivity
Dean J. Naisbitt,John Farrell,Gavin Wong,Jan P.H. Depta,Charlotte C. Dodd,Josephine E. Hopkins,Claire A. Gibney,David Chadwick,Werner J. Pichler,Munir Pirmohamed,B. Kevin Park +10 more
TL;DR: Evidence is provided that T cells are involved in the pathogenesis of some lamotrigine-hypersensitivity reactions, and the identification of drug-specific cells that express cutaneous lymphocyte antigen and type 1 cytokines after T-cell receptor activation is consistent with the clinical symptoms.
Journal ArticleDOI
Activation of T cells by carbamazepine and carbamazepine metabolites.
Ying Wu,Joseph P. Sanderson,John Farrell,Nicola S. Drummond,Anita Hanson,Elizabeth R. Bowkett,Neil G. Berry,Andrew V. Stachulski,Stephen E. Clarke,Werner J. Pichler,Munir Pirmohamed,B. Kevin Park,Dean J. Naisbitt +12 more
TL;DR: These data show that carbamazepine and certain stable carbazepine metabolites stimulate T cells rapidly via a direct interaction with MHC and specific T-cell receptors, providing a rationale for cross-sensitivity between the 2 drugs.
Journal ArticleDOI
Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation.
Dean J. Naisbitt,John Farrell,S. Fraser Gordon,James L. Maggs,Christoph Burkhart,Werner J. Pichler,Munir Pirmohamed,B. Kevin Park +7 more
TL;DR: The potential of SMX-NO to generate a potent antigen and cause cytotoxicity may in combination provide the signals necessary to induce a hypersensitivity reaction to SMX.