The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Method for formulating large diameter synthetic membrane vesicles

Systems, apparatus combinations and methods for producing a coating powder are provided wherein a stream of a powder coating precursor including at least one resin and at least one additional powder coating ingredient is contacted with a process fluid effective to reduce the viscosity of the powder coating precursor to allow processing of the powder coating precursor at a lower temperature.

Continuous processing of powder coating compositions

A coating powder consisting essentially of generally spherical particles ranging in size from less than 2 to about 40 microns, 75% of whose volume consists of particles of from about 2 to about 20 microns in size, is provided by dissolving the components of the coating powder in a supercritical fluid without the aid of a surfactant and spraying the solution into a zone whose pressure is less than that of the fluid. A very smooth continuous film of a cured thermosettable coating powder is achieved even when the film thickness is less than 1 mil, e.g., from about 0.2 and greater. The advantages of powder coatings may now be realized fully in the automobile and can industries.

Smooth thin film powder coating

A coating composition useful for a finish for automobiles and trucks in which the film forming binder contains reactive binder components of about (a) 25-90% by weight, based on the weight of the binder, of an acrylic polymer having at least two reactive anhydride groups composed of polymerized monomers of an ethylenically unsaturated anhydride and polymerized monomers from the group consisting of alkyl methacrylate, alkyl acrylate and any mixtures thereof, wherein the alkyl groups have 1-8 carbon atoms and the polymer has a weight average molecular weight of about 2,000-50,000; (b) 5-50% by weight, based on the weight of the binder, of a glycidyl component having at least two reactive glycidyl groups; (c) 5-50% by weight, based on the weight of the binder of an acid functional monomeric, oligomeric or polymeric compound which may or may not contain hydroxyl functionality; and the composition contains about 0.1-5% by weight; based on the weight of the binder, of a catalyst.

Multi-component coating composition comprising an anhydride containing polymer, a glycidyl component and an acid functional component

Protective coating composition which comprises dispersed fine particles of one or more of compounds selected from a metal salt of a higher fatty acid, a higher fatty acid having a melting point of 40°-90° C, and a wax having a melting point of 40°-90° C in an aqueous solution of a water-soluble film base and a surface-active agent having an HLB value of about 17 to 86 or silicon oil

Protective coating compositions

DRY, FREE-FLOWING POWDERS HAVING LITTLE OR NO ELECTROSTATIC CHARGE REACTION AND SUBSTANTIALLY FREE FROM WEBBEING ARE OBTAINED BY A PROESS WHICH COMPRISES THE STEPS OF: (1) PREPARING AN ACETONE SOLUTION OF AN ACRYLIC POLYMER, WHICH SOLUTION HAS A VISCOSITY OF LESS THAN ABOUT 13 SECONDS ($4 FORD CUP) AND THE RATIO OF ACETONE TO OTHER ORGANIC SOLVENTS IS AT LAST 3, (2) ADDING TO THE PRODUCT OF STEP (1) FROM 3 TO ABOUT 10 PERCENT ATER, BASED ON THE VOLUME OF ACETONE EMPLOYED, AND (3) SPRAY-DRYING THE PRODUCT OF STEP (2). THE POWDERS THUS OBTAINED ARE USEFUL AS COATING POWDER COMPOSITIONS WHICH CAN BE APPLIED BY EITHER ELECRROSTATIC SPRAYING OR FLUIDIZED BEADS, WITH EXCELLENT RESULTS.

John G. Munro

Papers

Process for spray-drying acrylic polymer solutions