John Gordon

TL;DR: It is found that, on culture, centrocytes isolated from human tonsil kill themselves within a few hours by apoptosis, not a feature of other tonsillar B cells.

TL;DR: It is shown in an in vitro system that EBV, through expression of the full set of eight virus-coded 'latent' proteins, can protect human B cells from programmed cell death (apoptosis), the deletion mechanism which normally restricts entry into memory.

TL;DR: Dual‐fluorescence studies on small lymphocytes confirm the presence of bcl‐2 protein in mitochondria but show that this is also present in other extra‐nuclear areas.

TL;DR: For more than a century follicles have been recognized as a site of intense cell proliferation and cell death, but the significance of this activity is beginning to emerge: antigen-driven B-cell proliferation, somatic mutation, positive and negative selection, and memory and plasma cell development all appear to take place within the follicle.

TL;DR: EBNA2 plays an important dual role in the process of B-cell activation to the lymphoblastoid phenotype; the protein can have a direct effect upon cellular gene expression and is also involved in activating the expression of a second virus-encoded effector protein, LMP.