J
John H. Boyd
Researcher at University of British Columbia
Publications - 129
Citations - 7620
John H. Boyd is an academic researcher from University of British Columbia. The author has contributed to research in topics: Septic shock & Sepsis. The author has an hindex of 39, co-authored 129 publications receiving 6127 citations. Previous affiliations of John H. Boyd include St. Paul's Hospital & McGill University Health Centre.
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Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality.
TL;DR: A more positive fluid balance both early in resuscitation and cumulatively over 4 days is associated with an increased risk of mortality in septic shock.
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A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Akram Khan,Cody Benthin,Brian Zeno,Timothy E Albertson,John H. Boyd,Jason D. Christie,Richard I. Hall,Germain Poirier,Juan J. Ronco,Mark Tidswell,Kelly Hardes,William Powley,Tracey J. Wright,Sarah Siederer,David Fairman,David A. Lipson,David A. Lipson,Andrew I. Bayliffe,Aili L. Lazaar,Aili L. Lazaar +19 more
TL;DR: GSK2586881 was well-tolerated in patients with ARDS, and the rapid modulation of RAS peptides suggests target engagement, although the study was not powered to detect changes in acute physiology or clinical outcomes.
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Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-κB dependent inflammatory response
TL;DR: Cardiomyocytes express most known Toll-like receptors, and of these, TLR2,TLR4 and TLR5 signal via NF-kappaB, resulting in decreased contractility and a concerted inflammatory response.
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Upper airway muscle inflammation and denervation changes in obstructive sleep apnea.
TL;DR: The data suggest that inflammatory cell infiltration and denervation changes affect not only the mucosa, but also the UA muscle of patients with OSA, which may have important implications for the ability to generate adequate muscular dilating forces during sleep.
Journal ArticleDOI
PCSK9 is a critical regulator of the innate immune response and septic shock outcome
Keith R. Walley,Katherine R. Thain,James A. Russell,Muredach P. Reilly,Nuala J. Meyer,Jane F. Ferguson,Jason D. Christie,Taka-aki Nakada,Chris Fjell,Simone A. Thair,Mihai Cirstea,John H. Boyd +11 more
TL;DR: Reduced PCSK9 function is associated with increased pathogen lipid clearance via the LDLR, a decreased inflammatory response, and improved septic shock outcome, and new work suggests thatPCSK9-targeted drugs should be tested in clinical trials with sepsis patients who carry the PCSK 9 gain-of-function variant.