Showing papers by "John H. Cardellina published in 1996"
TL;DR: The crude organic extract of Dendropanax arboreus was selected as a candidate for bioassayguided fractionation on the basis of its relatively selective cytotoxicity to a subset of cell lines within the National Cancer Institute's disease-oriented in vitro tumor-screening panel.
Abstract: The crude organic extract of Dendropanax arboreus was selected as a candidate for bioassay-guided fractionation on the basis of its relatively selective cytotoxicity to a subset of cell lines within the National Cancer Institute's disease-oriented in vitro tumor-screening panel. The major compound responsible for the in vitro cytotoxicity was falcarinol (1). Several other known compounds were isolated and found to be cytotoxic, including dehydrofalcarinol (2), a diynene (3), falcarindiol (4), and dehydrofalcarindiol (5). In addition, two novel polyacetylenes, dendroarboreols A (6) and B (7), were isolated and characterized by standard and inverse-detected NMR methods. Compounds were selected from this series for absolute stereochemical determination using the modified Mosher method and preliminary in vivo evaluation using a LOX melanoma mouse xenograft model.
138 citations
TL;DR: Bioassay-directed fractionation of the CH2Cl2-MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine and 2, and three new furoquinoline alkAloids, roxiamines A, B, and C (3-5).
Abstract: Bioassay-directed fractionation of the CH2Cl2-MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3-5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 microM, respectively), but 3-5 were inactive against HIV-1.
127 citations
TL;DR: The organic extract of the gorgonian Subergorgia suberosa was found to contain a novel cytotoxic sesquiterpene, suberosenone (1), as well as two known piscicidal sesQUiterpenes, buddledins C and D as mentioned in this paper.
55 citations
TL;DR: Nine new polyacetylenes, triangulynes A-H (1-8) and Triangulynic acid (9), have been isolated from the marine sponge Pellina triangulata through cytotoxicity-guided fractionation.
Abstract: Nine new polyacetylenes, triangulynes A-H (1-8) and triangulynic acid (9), have been isolated from the marine sponge Pellina triangulata (Oceanapiidae) through cytotoxicity-guided fractionation. Structural elucidations and stereochemistry assignments were based on chemical and spectral studies.
33 citations
TL;DR: Compound 1 protected target cells from the cytopathic effects of HIV-1 and HIV-2 and also exhibited potent inhibition of cellular DNA polymerases, as well as of the reverse transcriptases of HIV, but not of other retroviruses tested.
Abstract: Three galloylquinic acids, 1,3,4,5-tetra-O-galloylquinic acid (1), 3,4,5-tri-O-galloylquinic acid (2), and methyl 3,4,5-tri-O-galloylquinate (3) were isolated from the stem bark of the monotypic plant Lepidobotrys staudtii. Compound 1 protected target cells from the cytopathic effects of HIV-1 and HIV-2 and also exhibited potent inhibition of cellular DNA polymerases, as well as of the reverse transcriptases of HIV-1 and HIV-2, but not of other retroviruses tested.
19 citations
TL;DR: A new C43 acetylenic alcohol, vasculyne, was isolated by cytotoxicity-guided fractionation of the Caribbean sponge Cribrochalina vasculum by spectroscopic methods.
Abstract: A new C43 acetylenic alcohol, vasculyne (1), was isolated by cytotoxicity-guided fractionation of the Caribbean sponge Cribrochalina vasculum. The structure of 1 was determined by spectroscopic methods.
17 citations
TL;DR: A new kaurane diterpene was identified and identified as the major HIV-inhibitory constituent of the aqueous extract of fruits of a Xylopia sp. as mentioned in this paper.
Abstract: A new kaurane diterpene was isolated and identified as the major HIV-inhibitory constituent of the aqueous extract of fruits of a Xylopia sp. plant. Analysis of spectral data revealed the structure of the compound, xylopinic acid (1), a new diastereomer of a compound previously known only as a chemical/microbial transformation product.
12 citations
TL;DR: Fractionation of an HIV-inhibitory organic extract of Geniostoma antherotrichum afforded a glycoside derivative, which has been characterized as 2-hydroxy-3-O-beta-D-glucopyranosyl-benzoic acid on the basis of spectral analyses.
11 citations
4 citations
TL;DR: The organic extract of the gorgonian Subergorgia suberosa was found to contain a novel cytotoxic sesquiterpene, suberosenone (1), as well as two known piscicidal sesQUiterpenes, buddledins C and D.
Abstract: The organic extract of the gorgonian Subergorgia suberosa was found to contain a novel cytotoxic sesquiterpene, suberosenone (1), as well as two known piscicidal sesquiterpenes, buddledins C and D. The structure of 1 was defined by spectral methods, including 1D and 2D NMR experiments. Suberosenone, the first quadrone-class sesquiterpene from the marine biosphere, exhibited relatively potent cytotoxicity to solid tumor lines in comparison to leukemia lines in the NCI's 60 cell line in vitro screen.
2 citations