John H. Griffin

TL;DR: It is suggested that the recurrent thrombotic disease in this family is due to an inherited deficiency in protein C, a potent in vitro anticoagulant enzyme and an in vivo profibrinolytic agent.

TL;DR: This review summarizes insights gleaned from recent in vitro and in vivo studies of the direct cytoprotective effects of APC that include beneficial alterations in gene expression profiles, anti-inflammatory actions, antiapoptotic activities, and stabilization of endothelial barriers that suggest the possibility of developing APC variants with an improved profile for the ratio of cy toprotective to anticoagulant actions.

TL;DR: A straightforward methodology that has enabled us to rapidly analyze the compatibility of the native chemical ligation strategy for X-Cys ligation sites, where X is any of the 20 naturally occurring amino acids, and shows that all 20 amino acids are suitable for ligation.

TL;DR: There is evidence of a variety of mechanisms by which HDL is antithrombotic and thereby protective against arterial and venous thrombosis, including through the activation of prostacyclin synthesis.

TL;DR: It is reported that APC directly prevents apoptosis in hypoxic human brain endothelium through transcriptionally dependent inhibition of tumor suppressor protein p53, normalization of the pro-apoptotic Bax/Bcl-2 ratio and reduction of caspase-3 signaling.