A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a multi-cellular body portion operatively associated with a first anchor and a second anchor. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and have a depth that is substantially greater than the thickness of a majority of the members forming the closure device. The closure device can also include a member for promoting tissue growth. The delivery device can include an actuating assembly configured to partially deploy the closure device by a first movement, and deploy a second portion of the closure device by a second movement. The delivery device can also include a release assembly to selectively release or disconnect the closure device from the delivery device.

Methods, systems and devices for reducing the size of an internal tissue opening

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Methods and apparatus for renal neuromodulation

A robotic catheter manipulator assembly (300) may include a support member including a catheter manipulation base (308) and a sheath manipulation base (310) movable relative to each other and to the support member. Each manipulation base may be releasably connectable to a catheter cartridge (402) and a sheath cartridge (404). A drive mechanism (312) may be provided for moving the catheter and sheath manipulation bases (308,310) relative to each other and to the support member. The manipulation base (308) or the cartridge (402) may include a first element engageable with a complementary second element slidably engaged with the other one of the manipulation base or the cartridge for controlling movement of a component connected to the cartridge. The cartridge, may be a transseptal cartridge, a catheter cartridge or a sheath cartridge, the component may be a surgically insertable device such as a transseptal needle, a catheter or a sheath.

Robotic catheter manipulator assembly

A robotic catheter device cartridge may include a finger or a slider block generally disposed in a channel and engaged with a steering wire. The steering wire may control movement of a component having the steering wire engaged thereto when the finger or the slider block is linearly driven in a predetermined direction. The cartridge may be a transseptal cartridge having a transseptal needle connected thereto, a catheter cartridge having a catheter connected thereto, or a sheath cartridge having a sheath connected thereto.

Robotic catheter device cartridge

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.

Methods for renal neuromodulation

A component for use as or incorporation within a medical instrument navigable through body vessels of a human subject is provided. The component includes a tubular portion with an interrupted spiral defined by alternating cut and uncut sections. The interrupted spiral has a rigidity between that of a continuous cut spiral and an uncut tube. The rigidity of the interrupted spiral along its length may be varied by changing its pitch or the number of bridge members or the length of each bridge member. According to a method of manufacturing such a component, a tubular member and a cutting member are provided. At least one of the tubular member and the cutting member is moved though an angle defining a helical path with respect to the other, while the cutting member is alternated between cutting and not cutting the tubular member to form an interrupted spiral.

Interventional medical device component having an interrupted spiral section and method of making the same

https://repository.upenn.edu/cgi/viewcontent.cgi?article=1054&context=be_papers

A novel rodent neck pain model of facet-mediated behavioral hypersensitivity: implications for persistent pain and whiplash injury.

A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker member, which takes the form of a helical spring, extends from the distal end of the pusher member and is biased so as to lift the retaining ring off of the engagement member to ensure the release of the embolic device when the detachment member is withdrawn from the aperture of the engagement member.

Stretch resistant embolic coil delivery system with spring release mechanism

An implantable medical device detachment system is provided with a carrier member having a compressible portion at a distal end thereof. The compressible portion is moved to a compressed condition to allow an engagement member of the system to releasably engage an implantable device, such as an embolic coil. The carrier member and associated implantable device are fed through a body vessel to a target location, where the device is disengaged from the engagement member. The compressible portion then moves from the compressed condition to an elongated condition to completely separate the implantable device from the engagement member.

Implantable medical device detachment system and methods of using the same

A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. A fluid pressure source is coupled to the proximal end of the pusher member. An embolic device is retained at the distal end of the pusher member by a mechanical interlocking mechanism. The distal end of the pusher member includes a spiral ribbon section encircled by a tubular member. The tubular member or the distal end of the pusher member directs fluid from the fluid pressure source against the embolic device. The mechanical interlocking mechanism is disengaged from the embolic device and a fluid pressure is applied against the embolic device to ensure the release of the embolic device.

John H. Thinnes

Papers

Interventional medical device component having an interrupted spiral section and method of making the same

A novel rodent neck pain model of facet-mediated behavioral hypersensitivity: implications for persistent pain and whiplash injury.

Stretch resistant embolic coil delivery system with spring release mechanism

Implantable medical device detachment system and methods of using the same

Stretch resistant embolic coil delivery system with combined mechanical and pressure release mechanism