John J. Connolly

TL;DR: Cognitive performance improves substantially in this age span, with large effect sizes that differ by domain, which suggests that memory capacities have reached their apex before age 8.

TL;DR: Three approaches to identifying genetic factors that contribute to the pathogenesis of ASDs are reviewed: common variants and genome-wide association studies (GWAS); 2) rare variants and copy number variation (CNV) studies, and 3) familial forms of autism and the role of next-generation sequencing (NGS) methods.

TL;DR: The Philadelphia Neurodevelopmental Cohort is a large-scale study of child development that combines neuroimaging, diverse clinical and cognitive phenotypes, and genomics and is evolving to be a significant resource for the broader neuroscience community for studies of normal and abnormal neurodevelopment.

TL;DR: The PNC assessment mechanism yielded psychopathology data with strong factorial validity in a large diverse community cohort of genotyped youths and can advance understanding of complex inter-relationships among genes, cognition, brain, and behavior involved in neurodevelopment of common mental disorders.

TL;DR: Youths with spectrum symptoms had reduced accuracy across neurocognitive domains, reduced global functioning, and increased odds of depression, anxiety, behavioral disorders, substance use and suicidal ideation, which have public health relevance for prevention and early intervention.