J
John J. Reynolds
Researcher at University of Birmingham
Publications - 67
Citations - 5941
John J. Reynolds is an academic researcher from University of Birmingham. The author has contributed to research in topics: Collagenase & Matrix metalloproteinase. The author has an hindex of 38, co-authored 64 publications receiving 5728 citations. Previous affiliations of John J. Reynolds include University of Sussex.
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Journal ArticleDOI
Comparison of human stromelysin and collagenase by cloning and sequence analysis
S. E. Whitham,Gillian Murphy,Peter Angel,H.J. Rahmsdorf,Bryan J. Smith,Alan Howard Lyons,Harris T J R,John J. Reynolds,P Herrlich,Andrew J. P. Docherty +9 more
TL;DR: A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved and that they are secreted as proenzymes.
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Purification of rabbit bone inhibitor of collagenase.
TL;DR: Rabbit bones in tissue culture synthesize an inhibitor of collagenase during the first 4 days of culture, which blocked the activity of the metalloproteinases collagenase, gelatinase, neutral proteinase III (proteoglycanase), human leucocyte collagenase and gelatinases, but not thermolysin or bacterial collagenase.
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Binding of gelatinases A and B to type-I collagen and other matrix components.
TL;DR: It is concluded that gelatinases have different binding specificities from those previously documented for stromelysin and collagenase, which bind through their C-terminal domains to collagen fibrils.
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Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
Jun Shen,Edward C. Gilmore,Edward C. Gilmore,Christine A Marshall,Mary Haddadin,John J. Reynolds,Wafaa Eyaid,Adria Bodell,Brenda J. Barry,Danielle Gleason,Kathryn Allen,Vijay S. Ganesh,Bernard S. Chang,Arthur Grix,R. Sean Hill,Meral Topçu,Keith W. Caldecott,A. James Barkovich,Christopher A. Walsh,Christopher A. Walsh,Christopher A. Walsh +20 more
TL;DR: A previously unknown autosomal recessive disease characterized by microcephaly, early-onset, intractable seizures and developmental delay (denoted MCSZ) is described and multiple mutations in PNKP (polynucleotide kinase 3′-phosphatase) that result in severe neurological disease are identified.
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Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase.
TL;DR: Data suggest that there are two distinct major forms of gelatinolytic activity that also cause specific cleavage of type IV collagen, which are associated with a wide variety of normal connective tissue and haemopoietic cells, as well as many tumour cells.