John J. Roberts

TL;DR: In their sensitivity only to difunctional compounds and lack of an apparent DNA excision repair defect the phenotype of Walker cells strongly resembles those cells from human patients suffering from Fanconi's anaemia and also of yeast snm1 mutant cells.

TL;DR: The extract was used to detect lesions in the DNA of Chinese hamster cells treated in culture with N-methyl-N-nitrosourea and it was concluded that 3-methyladenine is excised from these cells with a half-life of about 2.3 h.

TL;DR: Caffeine was shown to be a novel inhibitor of NAD(P)H dehydrogenase (quinone) and also elicited the above protective effects and all of the above inhibitors were also shown to potentiate the toxic effects of menadione against the Walker cell.

TL;DR: Important questions are whether cells differ in their responses to platinum compounds and whether such differences are a function of the extent of drug uptake and binding of platinum to macromolecules and, if so, how much these differences are due to differences in their abilities to remove platinum adducts from their DNA by various excision repair processes.

TL;DR: Findings lend support to a previous proposition that the caffeine-induced inhibition of elongation of nascent DNA on a template containing chemical lesions results in an interference with the excision repair mechanism that removes these lesions.