J
John J. Turchi
Researcher at Indiana University
Publications - 82
Citations - 3442
John J. Turchi is an academic researcher from Indiana University. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 30, co-authored 71 publications receiving 2989 citations. Previous affiliations of John J. Turchi include Indiana University – Purdue University Indianapolis.
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Journal Article
Mdm-2 Phosphorylation by DNA-dependent Protein Kinase Prevents Interaction with p53
TL;DR: Evidence is provided that phosphorylation of Mdm-2 protein by DNA-dependent protein kinase (DNA-PK) blocks its ability to associate with p53 and regulate p53 transactivation, which supports a model by which DNA-PK activation by DNA damage and phosphorylated of MDM-2 renders the Mdn-2protein unable to inhibit p53transactivation, resulting in cell cycle arrest.
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Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology
TL;DR: The impact of NER on carcinogenesis, neurological function, sensitivity to environmental factors and sensitivity to cancer therapeutics, as well as from reconstitution studies and structural analyses of the proteins and enzymes that participate in this pathway are discussed.
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DNA repair targeted therapy: The past or future of cancer treatment?
Navnath Gavande,Pamela S. VanderVere-Carozza,Hilary D. Hinshaw,Shadia I. Jalal,Catherine R. Sears,Katherine S. Pawelczak,John J. Turchi +6 more
TL;DR: Recent advances are highlighted and previous failures in targeting DNA repair are discussed to pave the way for future DNA repair targeted agents and their use in cancer therapy.
Journal Article
Cisplatin-induced Apoptosis Proceeds by Caspase-3-dependent and -independent Pathways in Cisplatin-resistant and -sensitive Human Ovarian Cancer Cell Lines
Karen M. Henkels,John J. Turchi +1 more
TL;DR: A model in which cis platin-induced programmed cell death in the cisplatin-sensitive A2780 and -resistant CP70 and C30 cells proceeds via caspase-3-independent and -dependent pathways, respectively is supported.
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Chemotherapy induced DNA damage response: Convergence of drugs and pathways
Derek S. Woods,John J. Turchi +1 more
TL;DR: This review will focus on a series of chemotherapy-induced DNA lesions and highlight recent advances in the understanding of the DDR, the DNA repair pathways it activates and the cellular consequences of these converging pathways.