J
John L. Skousen
Researcher at University of Utah
Publications - 11
Citations - 925
John L. Skousen is an academic researcher from University of Utah. The author has contributed to research in topics: Single-unit recording & Superoxide dismutase. The author has an hindex of 8, co-authored 11 publications receiving 792 citations. Previous affiliations of John L. Skousen include United States Department of Veterans Affairs & Case Western Reserve University.
Papers
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Journal ArticleDOI
Progress towards biocompatible intracortical microelectrodes for neural interfacing applications
Mehdi Jorfi,John L. Skousen,John L. Skousen,Christoph Weder,Jeffrey R. Capadona,Jeffrey R. Capadona +5 more
TL;DR: This review provides a comprehensive reflection on the current understanding of the key failure modes that may impact intracortical microelectrode performance and presents the vision on the future directions of materials-based treatments for neural interfacing.
Journal ArticleDOI
Mechanically-compliant intracortical implants reduce the neuroinflammatory response
Jessica K. Nguyen,Jessica K. Nguyen,Daniel J. Park,John L. Skousen,Allison Hess-Dunning,Dustin J. Tyler,Dustin J. Tyler,Stuart J. Rowan,Christoph Weder,Christoph Weder,Jeffrey R. Capadona,Jeffrey R. Capadona +11 more
TL;DR: Overall, the data show strikingly that mechanically-compliant intracortical implants can reduce the neuroinflammatory response in comparison to stiffer systems.
Journal ArticleDOI
BBB leakage, astrogliosis, and tissue loss correlate with silicon microelectrode array recording performance
TL;DR: Using statistical approaches, it is found that blood-brain barrier leakiness and astrogliosis were both associated with reduced recording performance, and that tissue loss was negatively correlated with recording performance.
Book ChapterDOI
Reducing surface area while maintaining implant penetrating profile lowers the brain foreign body response to chronically implanted planar silicon microelectrode arrays.
John L. Skousen,Sr. Mary Elizabeth Merriam,Onnap Srivannavit,Gaytri Perlin,Kensall D. Wise,Patrick A. Tresco +5 more
TL;DR: The findings suggest that one method to improve the recording consistency and lifetime of implanted microelectrode arrays is to design implants that reduce the amount of macrophage activation at the biotic-abiotic interface and/or enhance the clearance or impact of their released factors.
Journal ArticleDOI
A strategy to passively reduce neuroinflammation surrounding devices implanted chronically in brain tissue by manipulating device surface permeability
TL;DR: The results suggest that increasing surface permeability of solid implanted devices to create a diffusion sink can be used to reduce the FBR and improve biocompatibility of chronic indwelling devices in brain tissue.