J
John Locke
Researcher at Johns Hopkins University School of Medicine
Publications - 9
Citations - 186
John Locke is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Spinal fusion & Internal medicine. The author has an hindex of 5, co-authored 7 publications receiving 133 citations. Previous affiliations of John Locke include Johns Hopkins University.
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Journal ArticleDOI
The biomechanics of pedicle screw augmentation with cement
Benjamin D. Elder,Sheng Fu L. Lo,Christina Holmes,Courtney Rory Goodwin,Thomas Kosztowski,Ioan A. Lina,John Locke,Timothy F. Witham +7 more
TL;DR: Polymethylmethacrylate and various calcium ceramics appear promising for the augmentation of pedicle screw fixation biomechanically in both osteoporosis and revision spine surgery models.
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A systematic review of the use of expandable cages in the cervical spine.
Benjamin D. Elder,Sheng Fu Lo,Thomas Kosztowski,C. Rory Goodwin,Ioan A. Lina,John Locke,Timothy F. Witham +6 more
TL;DR: Although expandable cervical cages are clearly beneficial in certain clinical situations, widespread use following all corpectomies is not justified due to their significantly greater cost compared to structural bone grafts or non-expandable VBRs, which can be utilized to achieve similar clinical outcomes.
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A systematic assessment of the use of platelet-rich plasma in spinal fusion.
Benjamin D. Elder,Christina Holmes,C. Rory Goodwin,Sheng Fu Lo,Varun Puvanesarajah,Thomas Kosztowski,John Locke,Timothy F. Witham +7 more
TL;DR: The role of PRP in augmentation of bone regeneration for the purpose of spinal fusion is discussed and the available animal and clinical studies are systematically reviewed to provide guidance on future research pathways as well as the potential role ofPRP in spinal fusion surgery.
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Effects of Intraoperative Intrawound Antibiotic Administration on Spinal Fusion: A Comparison of Vancomycin and Tobramycin in a Rat Model.
Wataru Ishida,Alexander Perdomo-Pantoja,Benjamin D. Elder,John Locke,Christina Holmes,Timothy F. Witham,Sheng Fu L. Lo +6 more
TL;DR: Intraoperative local application of vancomycin, particularly at a supraphysiological dosage, may have detrimental effects on fusion-mass formation, and spine surgeons should weigh the reduction in surgical site infection against a possible inhibitory effect on fusion.
Journal ArticleDOI
The Effects of High-Dose Parathyroid Hormone Treatment on Fusion Outcomes in a Rabbit Model of Posterolateral Lumbar Spinal Fusion Alone and in Combination with Bone Morphogenetic Protein 2 Treatment.
Christina Holmes,Wataru Ishida,Benjamin D. Elder,Sheng Fu L. Lo,Yunchan Amy Chen,Edmond Kim,John Locke,Maritza N. Taylor,Timothy F. Witham +8 more
TL;DR: Evaluating whether increasing dosage of PTH increases both volume and biomechanical stiffness of the resulting fusion masses and/or exhibits synergistic effects with low-dose bone morphogenetic protein 2 (BMP-2) resulted in increased fusion mass volume compared with autograft alone.