J
John M. Harrelson
Researcher at Duke University
Publications - 94
Citations - 6000
John M. Harrelson is an academic researcher from Duke University. The author has contributed to research in topics: Osteomalacia & Soft tissue sarcoma. The author has an hindex of 40, co-authored 94 publications receiving 5815 citations. Previous affiliations of John M. Harrelson include United States Department of Veterans Affairs & University of Oklahoma Medical Center.
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Journal Article
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
David M. Brizel,Sean P. Scully,John M. Harrelson,Lester J. Layfield,Joseph M. Bean,Leonard R. Prosnitz,Mark W. Dewhirst +6 more
TL;DR: The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of <10mm Hg (P=0.01); potential mechanisms and implications for clinical trial design are discussed.
Journal Article
Radiation Therapy and Hyperthermia Improve the Oxygenation of Human Soft Tissue Sarcomas
David M. Brizel,Sean P. Scully,John M. Harrelson,Lester J. Layfield,Richard K. Dodge,H C Charles,T. V. Samulski,Leonard R. Prosnitz,Mark W. Dewhirst +8 more
TL;DR: The magnitude of improvement in tumor oxygenation after the first HT fraction relative to pretreatment baseline was positively correlated with the amount of necrosis seen in the resection specimen, and increasing levels of tumor hypoxia were correlated with diminished metabolic status as measured by P-31 magnetic resonance spectroscopy.
Journal ArticleDOI
Metastatic carcinoma to skeletal muscle. A report of 15 patients.
TL;DR: From this study and a review of 52 cases reported in the literature, the authors are unable to find any clinical or radiographic characteristics that distinguish metastatic carcinoma to muscle from soft tissue sarcomas.
Journal Article
Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET.
D. N. Jones,D. N. Jones,G. B. McCowage,Henry Dirk Sostman,David M. Brizel,Lester J. Layfield,H C Charles,Mark W. Dewhirst,D. M. Prescott,Henry S. Friedman,John M. Harrelson,Sean P. Scully,R E Coleman +12 more
TL;DR: These initial results demonstrate changes in tumor accumulation of FDG during and after neoadjuvant therapy; these changes are dependent on the type of neoad Juvant therapy administered.
Journal ArticleDOI
Calcification of entheses associated with X-linked hypophosphatemic osteomalacia.
R. Polisson,Salutario Martinez,Maroon B. Khoury,R M Harrell,Kenneth W. Lyles,Nancy E. Friedman,John M. Harrelson,E Reisner,Marc K. Drezner +8 more
TL;DR: A generalized involvement of the entheses is found, with exuberant calcification of tendon and ligament insertions and of joint capsules, in 69 per cent of the subjects and the prevalence and extent of disease increased with age but were not correlated with sex.