John M. Shannon

TL;DR: It is demonstrated that endoderm develops from a brachyury+ population that also displays mesoderm potential, and this differentiation system is established as a unique murine model for studying the development and specification of this germ layer.

TL;DR: In this paper, a review of the role of diffusible factors in the development of the human lung is presented, showing that normal growth, morphogenetic patterning and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm.

TL;DR: The identification and characterization of an early embryoid body-derived colony, termed the transitional colony, which contains cell populations undergoing the commitment of mesoderm to the hematopoietic and endothelial lineages is described, suggesting a stage of development earlier than the blast cell colony and one that uniquely defines the requirement for a functional SCL/tal-1 gene for the progression to hematoplastic commitment.

TL;DR: The results suggest that in these mice TNF-alpha contributed to the development of pulmonary emphysema through chronic lung inflammation and activation of the elastolytic enzymes but by itself was unable to produce significant pulmonary fibrosis.

TL;DR: An important role is suggested for cell shape and cell-matrix interactions and maintenance of type II cell differentiation in alveolar type II epithelial cells cultured under conditions that might better reproduce their environment in vivo.