John R. Clamp

TL;DR: It is concluded that the presence of two or more O-acetyl groups on sialic acids inhibits enteric bacterial sialidases but that production of sialate O-acetylesterases by several populations of enteric bacteria lessens the likelihood that mucin oligosaccharide chains terminating in O- acetylated sIALic acids are protected from degradation.

TL;DR: The absorption of lactulose and mannitol in 20 patients with Crohn's disease limited to the ileum or colon was studied, and lactULose/mannitol excretion ratios were calculated, providing support for the concept that Crohn’s disease may be more extensive than is apparent macroscopically.

TL;DR: Rat CRP closely resembled human CRP in its amino acid composition, in having five subunits per molecule and in its electron microscopic appearance as a pentameric annular disc, but differed from murine SAP which is a major acute phase reactant.

TL;DR: C-reactive protein was discovered by Tillett and Francis’ in the sera of patients with various infectious and inflammatory diseases as a material which precipitated pneumococcal C-polysaccharide (CPS) and was called the “acute phase protein” and this term was subsequently applied to the large number of other plasma proteins.

TL;DR: Faecal extracts from ulcerative colitis patients had higher sialateO-acetyl esterase and glycosulfatase activity, while mucin sialidase activity was unchanged, and the UC mucin was degraded more rapidly by faecal enzyme extracts from both normal and UC subjects.