J
John R. Farley
Researcher at Loma Linda University
Publications - 53
Citations - 3900
John R. Farley is an academic researcher from Loma Linda University. The author has contributed to research in topics: Alkaline phosphatase & Bone cell. The author has an hindex of 33, co-authored 53 publications receiving 3814 citations.
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Journal ArticleDOI
Differential effects of phospholipids on skeletal alkaline phosphatase activity in extracts, in situ and in circulation
John R. Farley,Ursula M. Jorch +1 more
TL;DR: The observation that extracted human skeletal ALP lost its potential for inhibition byospholipids after treatment with phospholipase C further suggests that ALP activity may be released from cells during membrane turnover.
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Calcitonin increases the concentration of insulin-like growth factors in serum-free cultures of human osteoblast-line cells.
TL;DR: The data demonstrate that human osteoblast-line cells derived from normal human bone can respond to CT, and that those responses can include CT dose- and time-dependent increases in the extracellular levels of IGF-I and IGF-II.
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Characterization of a rapidly responding animal model for fluoride-stimulated bone formation.
TL;DR: Fourteen-day-old chicks treated with NaF for 2 weeks showed increases in bone-forming surface in the tibial metaphysis, with no change in the number of osteoblasts per length of forming surface with biphasic NaF dose dependence.
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Monofluorophosphate Physiology: The Effects of Fluoride on Bone
TL;DR: Fluoride is an effective agent in the treatment of osteoporosis and is the only available agent that is capable of producing a large increment in bone mass.
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In vitro evidence that local and systemic skeletal effectors can regulate 3[H]-thymidine incorporation in chick calvarial cell cultures and modulate the stimulatory actions(s) of embryonic chick bone extract.
TL;DR: These data demonstrate that local and systemic skeletal effectors can have effects on embryonic chick calvarial cells and regulate the activity of embryonic chick bone extracts to increase3[H]-thymidine incorporation, and mechanistic differences between the stimulatory actions of the effectors and the chick bone extract are illustrated.