J
John R. S. Newman
Researcher at California Institute for Quantitative Biosciences
Publications - 4
Citations - 4982
John R. S. Newman is an academic researcher from California Institute for Quantitative Biosciences. The author has contributed to research in topics: Gene & Five prime untranslated region. The author has an hindex of 3, co-authored 4 publications receiving 4471 citations. Previous affiliations of John R. S. Newman include Howard Hughes Medical Institute & University of California, San Francisco.
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Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
TL;DR: A ribosomesome-profiling strategy based on the deep sequencing of ribosome-protected mRNA fragments is presented and enables genome-wide investigation of translation with subcodon resolution and is used to monitor translation in budding yeast under both rich and starvation conditions.
Journal ArticleDOI
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
John R. S. Newman,Sina Ghaemmaghami,Sina Ghaemmaghami,Jan Ihmels,David K. Breslow,Matthew Noble,Joseph L. DeRisi,Joseph L. DeRisi,Jonathan S. Weissman +8 more
TL;DR: A strategy that pairs high-throughput flow cytometry and a library of GFP-tagged yeast strains to monitor rapidly and precisely protein levels at single-cell resolution is presented, revealing a remarkable structure to biological noise.
Journal ArticleDOI
Systems biology: many things from one.
TL;DR: A study breaking new ground by following the dynamics of such noise over time, in human cancer cells, and comparing different proteins reveals surprisingly long-lasting 'memories' of individual cell states, which can last for more than two generations in culture.