John Rozewicki

TL;DR: The Web interface for recently developed options for large data and interactive usage to refine sequence data sets and MSAs for multiple sequence alignment are explained.

TL;DR: MAFFT-DASH showed 10–20% improvement over standard MAFFT for MSA problems with weak similarity, in terms of Sum-of-Pairs (SP), a measure of how well a program succeeds at aligning input sequences in comparison to a reference alignment.

TL;DR: Repertoire Builder (https://sysimm.org/rep_builder/) is a method for generating atomic-resolution, three-dimensional models of B cell receptors or T cell receptors from their amino acid sequences.

TL;DR: Examining residue positions in the S protein that vary greatly across closely related viruses but are conserved in the subset of viruses that infect humans observed a bias in the composition of the amino acids that make up such residues toward more human- like, rather than virus-like, sequence motifs.

TL;DR: Recent developments in bioinformatics tools for analysis of BCR and TCR repertoires are reviewed, with an emphasis on those that incorporate structural features, along with methods for clustering such models.