Showing papers by "John W. Erdman published in 1980"
TL;DR: The effects of all-trans and 13-cis retinoic acid upon serum and liver lipids were investigated in Sprague-Dawley rats and feeding 315 micrograms/g diet of the 13- cis isomer was required to elicit a similar response to hypertriglyceridemia.
Abstract: The effects of all-trans and 13-cis retinoic acid upon serum and liver lipids were investigated in Sprague-Dawley rats Groups of rats were fed daily with 105, 210 and 315 micrograms/g diet of one of the retinoids for periods of up to 8 days Other groups were injected intraperitoneally (IP) daily with retinoids at levels equivalent to the daily intake of rats receiving 105 or 210 micrograms of retinoid/g diet All dietary concentrations of all-trans retinoic acid induced hypertriglyceridemia, however, only the highest dietary concentration of the 13-cis form caused this response Injection of the all-trans form consistently increased serum triglycerides, while 13-cis retinoic acid did so in only one case Retinoid-fed rats fasted for 6 hours before blood sampling demonstrated similar increases in serum triglycerides compared to their respective controls Also, retinoid administration reduced serum retinol at all levels tested with the all-trans form appearing to be more potent Growth and feed intake was somewhat reduced in rats receiving the highest level of all-trans retinoic acid Liver analysis did not reveal fatty liver or alterations in phospholipid, cholesterol, or vitamin A content in any groups monitored Our previous studies have shown induction of hypertriglyceridemia when rats were fed as low as 26 micrograms/g diet of all-trans retinoic acid The current studies would indicate that feeding 315 micrograms/g diet of the 13-cis isomer was required to elicit a similar response
60 citations
TL;DR: Results show that daily supplement of vitamin A increased serum triglycerides and reduced serum and hepatic cholesterol concentrations, and Serum and liver alterations were dependent on continued feeding.
Abstract: The effects of level and feeding frequency of retinoic acid (OIC) or retinyl acetate (YL) on the accumulation of lipids in the serum and liver of rats were investigated. Male Sprague-Dawley rats were fed ad libitum 1% cholesterol diets with or without supplemental OIC or YL. Vitamin A-fed groups included (per g of dry diet): 105 μg of OIC or 113 μg YL daily for 28 days, 735 μg OIC or 791 μg YL once each week for 28 days; and 735 or 105 μg OIC on day 1 or 105 μg OIC daily for the week experiment. Daily feeding of OIC or YL increased serum triglyceride concentrations as compared to controls. Several days after removal of OIC or 1 week after removal of supplemental YL from the rat diets, serum triglyceride concentrations returned to basal levels. Cholesterol feeding elevated serum cholesterol as well as hepatic cholesterol, total lipids and vitamin A concentrations. Daily OIC feeding depressed serum and hepatic cholesterol concentrations. These results show that daily supplement of vitamin A increased serum triglycerides and reduced serum and hepatic cholesterol concentrations. Serum and liver alterations were dependent on continued feeding.
16 citations