John W. McLean

TL;DR: It is concluded that some tumor vessels have a defective cellular lining composed of disorganized, loosely connected, branched, overlapping or sprouting endothelial cells that contribute to tumor vessel leakiness and may permit access of macromolecular therapeutic agents to tumor cells.

TL;DR: It is indicated that angiogenic endothelial cells in these models avidly bind and internalize cationic liposomes and liposome-DNA complexes but not other types ofliposomes, which raises the possibility of using cationsome- DNA complexes to target diagnostic or therapeutic agents selectively toAngiogenic blood vessels in tumors and sites of chronic inflammation.

TL;DR: Results showed that the cationic liposome-DNA complexes injected intravenously into CD-1 mice were internalized by endothelial cells in organ- and vessel-specific patterns that did not match any previously identified properties of the microvasculature.

TL;DR: Examination of gene expression in endothelial cells freshly isolated from lung capillaries after in vivo labeling with fluorescent cationic liposomes and purification by fluorescence-activated cell sorting finds familiar endothelial cell-associated genes and several tetraspanins had little or no previous association with endothelium.

TL;DR: This work sought to characterize changes in chronic airway inflammation and to determine whether corticosteroids that inhibit inflammation, such as dexamethasone, can also reduce microvascular remodelling.