J
Jon Chambers
Researcher at European Bioinformatics Institute
Publications - 9
Citations - 7214
Jon Chambers is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: chEMBL & The Internet. The author has an hindex of 9, co-authored 9 publications receiving 5406 citations. Previous affiliations of Jon Chambers include Wellcome Trust.
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Journal ArticleDOI
ChEMBL: a large-scale bioactivity database for drug discovery
Anna Gaulton,Louisa J. Bellis,A. Patrícia Bento,Jon Chambers,Mark Davies,Anne Hersey,Yvonne Light,Shaun McGlinchey,David Michalovich,Bissan Al-Lazikani,John P. Overington +10 more
TL;DR: ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds to maximize their quality and utility across a wide range of chemical biology and drug-discovery research problems.
Journal ArticleDOI
The ChEMBL database in 2017.
Anna Gaulton,Anne Hersey,Michal Nowotka,A. Patrícia Bento,Jon Chambers,David Mendez,Prudence Mutowo,Francis Atkinson,Louisa J. Bellis,Elena Cibrian-Uhalte,Mark Davies,Nathan Dedman,Anneli Karlsson,María Paula Magariños,John P. Overington,George Papadatos,Ines Smit,Andrew R. Leach +17 more
TL;DR: ChEMBL is an open large-scale bioactivity database that includes the annotation of assays and targets using ontologies, the inclusion of targets and indications for clinical candidates, addition of metabolic pathways for drugs and calculation of structural alerts.
Journal ArticleDOI
The ChEMBL bioactivity database: an update
A. Patrícia Bento,Anna Gaulton,Anne Hersey,Louisa J. Bellis,Jon Chambers,Mark Davies,Felix A. Kruger,Yvonne Light,Lora Mak,Shaun McGlinchey,Michal Nowotka,George Papadatos,Rita Santos,John P. Overington +13 more
TL;DR: More comprehensive tracking of compounds from research stages through clinical development to market is provided through the inclusion of data from United States Adopted Name applications and a new richer data model for representing drug targets has been developed.
Journal ArticleDOI
ChEMBL: towards direct deposition of bioassay data
David Mendez,Anna Gaulton,A. Patrícia Bento,Jon Chambers,Marleen De Veij,Eloy Felix,María Paula Magariños,Juan F Mosquera,Prudence Mutowo,Michal Nowotka,María Gordillo-Marañón,Fiona M. I. Hunter,Laura Junco,Grace Mugumbate,Milagros Rodríguez-López,Francis Atkinson,Nicolas Bosc,Chris J Radoux,Aldo Segura-Cabrera,Anne Hersey,Andrew R. Leach +20 more
TL;DR: Several important improvements have been made to ChEMBL in the last two years, including more robust capture and representation of assay details; a new data deposition system, allowing updating of data sets and deposition of supplementary data; and a completely redesigned web interface, with enhanced search and filtering capabilities.
Journal ArticleDOI
SureChEMBL: a large-scale, chemically annotated patent document database.
George Papadatos,Mark Davies,Nathan Dedman,Jon Chambers,Anna Gaulton,James Siddle,Richard Koks,Sean A. Irvine,Joe Pettersson,Nicholas T. Goncharoff,Anne Hersey,John P. Overington +11 more
TL;DR: SureChEMBL provides access to a previously unavailable, open and timely set of annotated compound-patent associations, complemented with sophisticated combined structure and keyword-based search capabilities against the compound repository and patent document corpus.