Jon W. Gordon

TL;DR: The results demonstrate that genes can be introduced into the mouse genome by direct insertion into the nuclei of early embryos by microinjected into pronuclei of fertilized mouse oocytes.

TL;DR: It is reported here that high expression of this altered gene in the central nervous systems of transgenic mice is associated with an age-related rapidly progressive decline of motor function accompanied by degenerative changes of motoneurons within the spinal cord, brain stem, and neocortex, indicating a causative relationship between altered SOD activity and motoneuron degeneration.

TL;DR: The evidence presented indicates the covalent association of injected DNA with host sequences, and transmission of such linked sequences in a Mendelian distribution to two succeeding generations of progeny.

TL;DR: This work inserts into the germline of mice either a mutant or wild-type allele from a patient with retinitis pigmentosa and a missense mutation (P23H) in the rhodopsin gene, helping to establish the pathogenicity of mutant human P23H rod opsin and suggest that overexpression of wild- type human rods opsin leads to a remarkably similar photoreceptor degeneration.

TL;DR: The results demonstrate that zona drilling is a safe, effective method of increasing the efficiency of fertilization in vitro and may be useful both in agriculture and medicine for conferring fertility upon males with low sperm counts.