Showing papers in "Neuron in 1992"

TL;DR: A prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein, suggesting molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.

TL;DR: The subunit stoichiometry of the mammalian K+ channel KV1.1 (RCK1) was examined by linking together the coding sequences of 2-5 K+Channel subunits in a single open reading frame and tagging the expression of individual subunits with a mutation that altered the sensitivity of the channel to block by external tetraethylammonium ion.

TL;DR: Induction of homosynaptic LTD requires an NMDA receptor-dependent change in postsynaptic Ca2+ which may be distinct from that required for long-term potentiation.

TL;DR: Three cDNA clones were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor to form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.

TL;DR: By using antibodies specific for some of the inserts that distinguish the various isoforms and label PHFs, a correspondence betweenPHFs, abnormal bands, and isoforms is established and is a necessary step in unravelling the molecular pathogenesis of PHFs.

TL;DR: Mutational analysis revealed that both the positive charge and the size of the amino acid side chain located at the Q/R site control the divalent permeability of homomeric channels.

TL;DR: Astrocytic Ca2+ waves are present under these circumstances and that these waves can be triggered by the firing of glutamatergic neuronal afferents with latencies as short as 2 s, suggesting that astrocytes may have a much more dynamic and active role in brain function than has been generally recognized.

TL;DR: The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons but had no effect on identified T-type, L- type, or N-type currents in a variety of central and peripheral neurons.

TL;DR: The results demonstrate a new pathway for NO regulation of physiological function that is not via cGMP, but instead involves reactions with membrane-bound thiol groups on the NMDA receptor-channel complex.

TL;DR: In this paper, the authors found that the NGF-related neurotrophins, brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are also retrogradely transported by distinct populations of peripheral and central nervous system neurons in the adult.

TL;DR: It is revealed that VIP receptor mRNA is widely distributed in neuronal cells of the adult rat brain, with a relatively high expression in the cerebral cortex and hippocampus, suggesting that they constitute a new subfamily of the Gs protein-coupled receptors.

TL;DR: The recently sequenced trp protein represents a class of light-sensitive channel required for inositide-mediated Ca2+ entry and it is suggested that this process is necessary for maintained excitation during intense illumination in fly photoreceptors.

TL;DR: In rat brain, the cellular localization of a phosphoinositide-linked metabotropic glutamate receptor (mGluR1 alpha) was demonstrated using antibodies that recognize the C-terminus of the receptor.

TL;DR: Pertussis toxin and phorbol ester produced distinct effects on the three transduction cascades, implying that mGluR1 independently links to the multiple transduction pathways probably through different G proteins.

TL;DR: It is reported that stimulation inducing long-term potentiation in the CA1 pyramidal cell layer of the hippocampus evokes significant increases in both BDNF and NT-3 mRNAs in CA1 neurons, which suggest that relatively normal levels of activity may regulate region-specific neurotrophin levels in the hippocampus.

TL;DR: Coexpression of GluR5(R) and KA-2 produces channel activity, whereas homomeric expression of either subunit does not, and results suggest possible in vivo partnership relations for high affinity kainate receptors.

TL;DR: Several results are discussed that lead to a view that cells in the visual system are endowed with dynamic properties, influenced by context, expectation, and long-term modifications of the cortical network.

TL;DR: This work has determined the subset of AMPA receptor subunits expressed by single cerebellar Purkinje cells in culture, and found that each single cell expresses the messenger RNAs encoding the following five subunits: the flip and flop versions of GluR1 and GLUR2 as well as GluGluR3flip, GLuR2 being the most abundant.

TL;DR: The results define complementary distributions of N- and L-type calcium channels in dendrites, nerve terminals, and cell bodies of most central neurons and support distinct functional roles in calcium-dependent electrical activity, intracellular calcium regulation, and neurotransmitter release for these two channel types.

TL;DR: The results of the in situ hybridization experiments suggest that neurotrophins have roles other than being target-derived factors that support neuron survival during developmental cell death (neurotrophic hypothesis), but may be transported in an orthograde fashion in neurons and released from axon terminals.

TL;DR: It is proposed that UNC-6 is a component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis that guides pioneer axons and migrating cells along the body wall in C. elegans.

TL;DR: The alpha 1 subunit directs the recombinant expression of a dihydropyridine-sensitive L-type Ca2+ channel when coexpressed with the beta (beta 2) and the alpha 2 (alpha 2b) subunits in Xenopus oocytes.

TL;DR: It is concluded that opsin is constrained to an inactive conformation by a salt bridge between Lys-296 and Glu-113, the Schiff base counterion of visual pigment rhodopsin.

TL;DR: The data indicate that transient activation of p21ras and, consequently, ERKs is not sufficient for induction of neuronal differentiation, and that prolonged ERK activity is required: a consequence of sustained activation ofp21ras by the growth factor receptor protein tyrosine kinase.

TL;DR: A new Conus peptide is described that is an effective inhibitor of omega-CgTx-GVIA-resistant synaptic transmission and defines a general approach for obtaining ligands with novel receptor subtype specificity from Conus.

TL;DR: Both soluble and membrane-associated human brain APP (10(-10) M) significantly increased neurite length and branching in pheochromocytoma PC12 cells, but did not affect the number of neurites per cell.

TL;DR: The results suggest that alternative splicing gives rise to a large family of functionally diverse, calcium-activated potassium channels, which are probably related to closely related proteins of about 1200 aa.