J
Jonathan C. Rupp
Researcher at Indiana University
Publications - 4
Citations - 369
Jonathan C. Rupp is an academic researcher from Indiana University. The author has contributed to research in topics: RNA & Viral replication. The author has an hindex of 4, co-authored 4 publications receiving 301 citations. Previous affiliations of Jonathan C. Rupp include University of Alaska Anchorage.
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Journal ArticleDOI
Alphavirus RNA synthesis and non-structural protein functions.
TL;DR: This review describes what is currently understood about the regulation of alphavirus RNA synthesis, the roles of the viral non-structural proteins in this process and the functions of cis-acting RNA elements in replication, and points to open questions within the field.
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Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro.
Jon K. Rubach,Brian R. Wasik,Jonathan C. Rupp,Richard J. Kuhn,Richard W. Hardy,Janet L. Smith +5 more
TL;DR: The successful expression and purification of Sindbis virus RNA-dependent RNA polymerase is reported in a bacterial system, in which nsP4 is expressed as an N-terminal SUMO fusion protein, and this purified enzyme is able to produce minus-strand RNA de novo from plus- Strand templates.
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Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication
Jonathan C. Rupp,Manon Locatelli,Manon Locatelli,Alexis Grieser,Andrea Ramos,Patricia J. Campbell,Hong Yi,John Steel,Jason L. Burkhead,Eric Bortz +9 more
TL;DR: These results demonstrate that intracellular copper regulates the influenza virus life cycle, with potentially distinct mechanisms in specific cellular compartments, providing a new avenue for drug development and studies of influenza virus pathogenesis.
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Requirement for the amino-terminal domain of sindbis virus nsP4 during virus infection.
TL;DR: The results imply that nsP4's amino-terminal domain participates in distinct interactions with other nsPs in the context of differentially functioning RNA synthetic complexes, and flexibility in this domain is important for viral RNA synthesis.