J
Jonathan C. W. Edwards
Researcher at University College London
Publications - 32
Citations - 7086
Jonathan C. W. Edwards is an academic researcher from University College London. The author has contributed to research in topics: Rheumatoid arthritis & Rituximab. The author has an hindex of 20, co-authored 32 publications receiving 6830 citations.
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Journal ArticleDOI
Antibodies to citrullinated peptides and risk of coronary heart disease.
Geraldine Cambridge,Jayshree Acharya,Jackie A. Cooper,Jonathan C. W. Edwards,Steve E. Humphries +4 more
TL;DR: The genesis and fine specificity of ACPA in patients with atherosclerosis, in the absence of Rheumatoid arthritis, may prove worthy of further investigation.
Book ChapterDOI
B Lymphocyte Depletion in Rheumatoid Arthritis:Targeting of CD20
TL;DR: The effects of B lymphocyte depletion lend increasing support to the idea that both the inflammatory effector mechanism and the underlying immunoregulatory disturbance in RA are driven by autoantibody rather than T cells.
Journal ArticleDOI
B-cell-activating factor receptor expression on naive and memory B cells: relationship with relapse in patients with rheumatoid arthritis following B-cell depletion therapy
Inmaculada de la Torre,Rita A Moura,Maria J. Leandro,Jonathan C. W. Edwards,Geraldine Cambridge +4 more
TL;DR: BAFF-R expression was significantly reduced on both naive and memory B cells in patients at relapse, regardless of the relationship with B-cell repopulation or serum BAFF levels.
Journal ArticleDOI
B cell depletion therapy for patients with systemic lupus erythematosus results in a significant drop in anticardiolipin antibody titres.
Yiannis Ioannou,Anastasia Lambrianides,Geraldine Cambridge,Maria J. Leandro,Jonathan C. W. Edwards,David A. Isenberg +5 more
TL;DR: This small observational study is the first to demonstrate that BCDT results in a significant reduction in levels of IgG aCL, which is implicated in the pathogenesis of the antiphospholipid syndrome.