J
Jonathan C. W. Edwards
Researcher at University College London
Publications - 32
Citations - 7086
Jonathan C. W. Edwards is an academic researcher from University College London. The author has contributed to research in topics: Rheumatoid arthritis & Rituximab. The author has an hindex of 20, co-authored 32 publications receiving 6830 citations.
Papers
More filters
Journal ArticleDOI
B cell depletion therapy in systemic lupus erythematosus: long-term follow-up and predictors of response
Kristine P Ng,Geraldine Cambridge,Maria J. Leandro,Jonathan C. W. Edwards,Michael R. Ehrenstein,David A. Isenberg +5 more
TL;DR: Although the long-term safety profile of BCDT is favourable, ongoing vigilance is recommended, and autoantibody profiling may help identify patients who will have a more sustained response.
Journal ArticleDOI
Induction of tumor necrosis factor α production by adhered human monocytes: A key role for Fcγ receptor type IIIA in rheumatoid arthritis
TL;DR: A dominant role for FcgammaRIIIA is suggested in the induction of both TNFalpha and IL-1alpha production by human macrophages in rheumatoid arthritis following receptor ligation by small immune complexes.
Journal ArticleDOI
Repeated B cell depletion in treatment of refractory systemic lupus erythematosus
Kristine P Ng,Maria J. Leandro,Jonathan C. W. Edwards,Mike Ehrenstein,Geraldine Cambridge,David A. Isenberg +5 more
TL;DR: Re-treatment with B cell depletion of patients with severe SLE is safe and may be effective for 6–12 months on average, and most patients tolerate re-treatment very well.
Journal ArticleDOI
Total serum immunoglobulin levels in patients with RA after multiple B-cell depletion cycles based on rituximab: relationship with B-cell kinetics
Inmaculada de la Torre,Maria J. Leandro,Lara Valor,E Becerra,Jonathan C. W. Edwards,Geraldine Cambridge +5 more
TL;DR: The association of low IgM in patients with a discordant pattern of relapse suggests that underlying defects in B cells relating to survival and maturation into Ig-secreting cells, as well as attrition of IgG plasma cells may be contributing to low sIg levels in some patients.
Journal ArticleDOI
Jekyll and Hyde: the transformation of HLA-B27
TL;DR: HLA-B27 can adopt a homodimeric form and in spondyloarthritis, such aberrant expression of B27 may override a tissue-specific inhibition of major histocompatibility complex (MHC) class I-dependent events, leading to inflammation and fibrosis.