J
Jong Wan Park
Researcher at New Generation University College
Publications - 192
Citations - 8541
Jong Wan Park is an academic researcher from New Generation University College. The author has contributed to research in topics: Cancer cell & Cancer. The author has an hindex of 49, co-authored 186 publications receiving 7442 citations. Previous affiliations of Jong Wan Park include Seoul National University & National Institutes of Health.
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Journal ArticleDOI
YC-1: A Potential Anticancer Drug Targeting Hypoxia-Inducible Factor 1
Eun-Jin Yeo,Yang-Sook Chun,Young-Suk Cho,Jin-Ho Kim,June-Chul Lee,Myung-Suk Kim,Jong Wan Park +6 more
TL;DR: The inhibition of HIF-1 alpha activity in tumors from YC-1-treated mice is associated with blocked angiogenesis and an inhibition of tumor growth and has the potential to become the first antiangiogenic anticancer agent to target Hif-1alpha.
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STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells
Joo Eun Jung,Hyun Gyu Lee,Ik Hyun Cho,Doo Hyun Chung,Sun-Hee Yoon,Young Mok Yang,Jung Weon Lee,Seongwon Choi,Jong Wan Park,Sang-Kyu Ye,Myung-Hee Chung +10 more
TL;DR: Findings provide compelling evidence that a causal relationship exists between STAT3 activation and HIF‐1‐dependent angiogenesis and suggest that therapeutic modalities designed to disrupt STAT3 signaling hold considerable promise for the blocking tumor growth and enhancing apoptosis of cancer cells and tissues.
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Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway.
TL;DR: The results suggest that HIF-1&agr; plays an important role in the induction of VEGF in nonischemic and mechanically stressed myocardium, and that this is regulated by stretch-activated channels and the PI3K/Akt/FRAP pathway.
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Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition.
TL;DR: It is found that curcumin inhibits Hif-1 activity and that this in turn down-regulates genes targeted by HIF-1, and the results suggest that the anticancer activity ofCurcumin is attributable to H IF-1 inactivation by ARNT degradation.
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New anticancer strategies targeting HIF-1.
TL;DR: It is proposed that YC-1 is a good lead compound for the development of new anti-HIF-1, anticancer agents, which would improve the prognoses of many cancer patients.