J
Jorge R. Dominguez-Rodriguez
Researcher at Mexican Social Security Institute
Publications - 15
Citations - 408
Jorge R. Dominguez-Rodriguez is an academic researcher from Mexican Social Security Institute. The author has contributed to research in topics: Apoptosis & Caspase. The author has an hindex of 11, co-authored 15 publications receiving 370 citations. Previous affiliations of Jorge R. Dominguez-Rodriguez include University of Guadalajara.
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Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence
Georgina Hernández-Flores,Pablo C Ortiz-Lazareno,José Manuel Lerma-Díaz,Jorge R. Dominguez-Rodriguez,Luis Felipe Jave-Suárez,Adriana Aguilar-Lemarroy,Ruth de Celis-Carrillo,Susana del Toro-Arreola,Yessica C Castellanos-Esparza,Alejandro Bravo-Cuellar,Alejandro Bravo-Cuellar +10 more
TL;DR: In vitro whether PTX alone or in combination with CIS induces apoptosis and/or senescence in cervix cancer HeLa and SiHa cell lines infected with HPV types 16 and 18, as well as in immortalized keratinocytyes HaCaT cells is studied.
Journal ArticleDOI
MG132 proteasome inhibitor modulates proinflammatory cytokines production and expression of their receptors in U937 cells: involvement of nuclear factor‐κB and activator protein‐1
Pablo C Ortiz-Lazareno,Georgina Hernández-Flores,Jorge R. Dominguez-Rodriguez,José Manuel Lerma-Díaz,Luis Felipe Jave-Suárez,Adriana Aguilar-Lemarroy,Piedad C. Gomez-Contreras,Daniel Scott-Algara,Alejandro Bravo-Cuellar,Alejandro Bravo-Cuellar +9 more
TL;DR: In this study, the human monocyte cell line U937 stimulated with lipopolysaccharide and phorbol 12‐myristate 13‐acetate as a model is used to investigate the in vitro effects of MG132, a proteasome inhibitor, on the release of proinflammatory cytokines and their receptors and on the expression of their membrane and soluble receptors.
Journal ArticleDOI
Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss
Pablo C Ortiz-Lazareno,Alejandro Bravo-Cuellar,Alejandro Bravo-Cuellar,José Manuel Lerma-Díaz,José Manuel Lerma-Díaz,Luis Felipe Jave-Suárez,Adriana Aguilar-Lemarroy,Jorge R. Dominguez-Rodriguez,Jorge R. Dominguez-Rodriguez,Oscar Gonzalez-Ramella,Ruth De Celis,Paulina Gómez-Lomelí,Paulina Gómez-Lomelí,Georgina Hernández-Flores +13 more
TL;DR: MG132 sensitizes U937 leukemia cells to DOX-induced apoptosis, increasing its anti-leukemic effectiveness and decreasing caspase-3 activation, as well as mitochondrial membrane potential loss.
Journal ArticleDOI
Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence.
Alejandro Bravo-Cuellar,Alejandro Bravo-Cuellar,Pablo C Ortiz-Lazareno,José Manuel Lerma-Díaz,Jorge R. Dominguez-Rodriguez,Luis Felipe Jave-Suárez,Adriana Aguilar-Lemarroy,Susana del Toro-Arreola,Ruth de Celis-Carrillo,José Ernesto Sahagún-Flores,Javier E García de Alba-García,Georgina Hernández-Flores +11 more
TL;DR: Surprisingly, in spite of the antitumor activity displayed by PTX, the results indicate that methylxantine, per se does not induce senescence; however it inhibits Senescence induced by ADR and at the same time increases apoptosis.
Journal ArticleDOI
In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline. Involvement of caspase cascades and IkappaBalpha phosphorylation.
José Manuel Lerma-Díaz,Georgina Hernández-Flores,Jorge R. Dominguez-Rodriguez,Pablo C Ortiz-Lazareno,Piedad C. Gomez-Contreras,Ramon Cervantes-Munguia,Ramon Cervantes-Munguia,Daniel Scott-Algara,Adriana Aguilar-Lemarroy,Luis Felipe Jave-Suárez,Alejandro Bravo-Cuellar,Alejandro Bravo-Cuellar +11 more
TL;DR: Whether in vivo and in vitro pentoxifylline sensitizes hematological tumor cells to adriamycin (ADM)-induced apoptosis and the involvement of caspase cascades and phosphorylated forms of IκBα is investigated to investigate the mechanisms of drug resistance.