Showing papers by "José F. Siqueira published in 2015"
TL;DR: The dentin and pulp conditions in teeth affected by cracks and attrition were evaluated, finding that cracks are always colonized with bacterial biofilms and the pulp tissue response varies according to the location, direction, and extent of the crack.
65 citations
TL;DR: Streptococcus species, members of the Actinobacteria phylum, and P. alactolyticus were the most prevalent taxa in the apical canal system and dominated the bacterial populations in many cases of post-treatment apical periodontitis.
64 citations
TL;DR: Different forms of extraradicular infection were associated with symptoms in these cases, leading to short-term endodontic failure only solved by periapical surgery.
55 citations
TL;DR: Several bacterial taxa were found in advanced caries lesions in teeth with exposed pulps, and some of them were significantly associated with symptoms, suggesting a role for these taxa in the etiology of irreversible pulpitis is suspected.
54 citations
TL;DR: No significant difference was observed between the 2 systems in disinfecting the canals of teeth with post-treatment apical periodontitis.
39 citations
TL;DR: This first report of SCFAs in infected root canals suggests that these molecules may play a role in the pathogenesis of apical periodontitis.
18 citations
TL;DR: The type of inflammatory infiltrate present in periradicular cysts appears to influence the expression of RANK, RANKL, and OPG and is likely to have increased osteolytic activity because of a higher RankL/OPG ratio.
16 citations
01 Jan 2015
TL;DR: The clinician should be aware that, when performing root canal treatment or retreatment, he or she is dealing with a biofilm infection, which may be very difficult to reach and eradicate and may require special strategies for successful management.
Abstract: Recent evidence brought about by morphological studies has indicated that apical periodontitis is a disease caused by or at least highly associated with bacterial biofilms. Histobacteriological studies revealed that biofilm-like structures are the main form in which bacteria infecting the root canal system are organized. Bacterial biofilms can be found in virtually all areas of the root canal system, including the main canal, apical and lateral ramifications, isthmuses, and recesses. Biofilms are very frequent in the apical part of root canals of teeth with primary or posttreatment apical periodontitis. Morphology of endodontic biofilms can vary from case to case and a unique pattern has not been established. Bacterial biofilms are expected to be even more prevalent in the root canals of teeth associated with long-standing pathologic processes, including large apical radiolucencies and cysts. The bacterial diversity associated with endodontic biofilms is broader than previously anticipated, and several culture-difficult or as-yet-uncultivated bacteria can participate in these communities. The clinician should be aware that, when performing root canal treatment or retreatment, he or she is dealing with a biofilm infection, which may be very difficult to reach and eradicate and may require special strategies for successful management.
1 citations