J
José R. Rodríguez-Medina
Researcher at University of Puerto Rico, Medical Sciences Campus
Publications - 24
Citations - 379
José R. Rodríguez-Medina is an academic researcher from University of Puerto Rico, Medical Sciences Campus. The author has contributed to research in topics: Saccharomyces cerevisiae & Gene. The author has an hindex of 9, co-authored 24 publications receiving 331 citations. Previous affiliations of José R. Rodríguez-Medina include University of Puerto Rico.
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Journal ArticleDOI
Redundant or separate entities?—roles of Twist1 and Twist2 as molecular switches during gene transcription
TL;DR: Twist1 and Twist2 are highly conserved members of the Twist subfamily of bHLH proteins responsible for the transcriptional regulation of the developmental programs in mesenchymal cell lineages as discussed by the authors.
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Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer
Tessa Humphries-Bickley,Linette Castillo-Pichardo,Linette Castillo-Pichardo,Eliud Hernandez-O'Farrill,Luis D. Borrero-Garcia,Ingrid Forestier-Roman,Yamil Gerena,Manuel Blanco,Michael John Rivera-Robles,José R. Rodríguez-Medina,Luis A. Cubano,Cornelis P. Vlaar,Suranganie Dharmawardhane +12 more
TL;DR: MBQ-167 is 10× more potent than other currently available Rac/Cdc42 inhibitors and has the potential to be developed as an anticancer drug, as well as a dual inhibitory probe for the study of Rac and Cdc42.
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The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast.
Linghuo Jiang,Malcolm Whiteway,Malcolm Whiteway,Carlos Ramos,José R. Rodríguez-Medina,Shi-Hsiang Shen,Shi-Hsiang Shen +6 more
TL;DR: This work has identified a novel PP2C phosphatase (CaPtc7p) from the human fungal pathogen Candida albicans and designated YHR076w as ScPTC7, the seventh PP 2C-like gene in S. cerevisiae, which has been identified as a potential homologue in the budding yeast Saccharomyces Cerevisiae.
Journal ArticleDOI
Molecular analysis of the Saccharomyces cerevisiae YHR076w gene.
C. W. Ramos,C. W. Ramos,Ulrich Güldener,Sabine Klein,Johannes H. Hegemann,S. Gonzalez,José R. Rodríguez-Medina +6 more
TL;DR: It is demonstrated that open reading frame (ORF) YHR076w on chromosome VIII of Saccharomyces cerevisiae that was previously described as a hypothetical gene is expressed and promoter activity assays indicate that YHR 076w transcription is regulated by carbon source and primarily by ethanol.
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Prevalence and distribution of introns in non-ribosomal protein genes of yeast.
TL;DR: Observations reveal an intriguing distinction between the distributions of ribosomal protein and non-ribosomalprotein intron lengths, suggestive of distinct, gene class-specific evolutionary pressures.