T
Tessa Humphries-Bickley
Researcher at University of Puerto Rico, Medical Sciences Campus
Publications - 4
Citations - 320
Tessa Humphries-Bickley is an academic researcher from University of Puerto Rico, Medical Sciences Campus. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 3, co-authored 4 publications receiving 263 citations.
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Journal ArticleDOI
Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
Brenda L. Montalvo-Ortiz,Linette Castillo-Pichardo,Eliud Hernandez,Tessa Humphries-Bickley,Alina De La Mota-Peynado,Luis A. Cubano,Cornelis P. Vlaar,Suranganie Dharmawardhane +7 more
TL;DR: It is demonstrated that EHop-016 inhibits Rac activity in the MDA-MB-435 metastatic cancer cells that overexpress Rac and exhibits high endogenous Rac activity, and holds promise as a targeted therapeutic agent for the treatment of metastatic cancers with high Rac activity.
Journal ArticleDOI
The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model
Linette Castillo-Pichardo,Linette Castillo-Pichardo,Tessa Humphries-Bickley,Columba de la Parra,Ingrid Forestier-Roman,Magaly Martínez-Ferrer,Eliud Hernandez,Cornelis P. Vlaar,Yancy Ferrer-Acosta,Anthony V Washington,Luis A. Cubano,José F. Rodríguez-Orengo,Suranganie Dharmawardhane +12 more
TL;DR: EHop-016 has potential as an anticancer compound to block cancer progression via multiple Rac-directed mechanisms and affected cell viability by down-regulating Akt and Jun kinase activities and c-Myc and Cyclin D expression, as well as increasing caspase 3/7 activities in metastatic cancer cells.
Journal ArticleDOI
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer
Tessa Humphries-Bickley,Linette Castillo-Pichardo,Linette Castillo-Pichardo,Eliud Hernandez-O'Farrill,Luis D. Borrero-Garcia,Ingrid Forestier-Roman,Yamil Gerena,Manuel Blanco,Michael John Rivera-Robles,José R. Rodríguez-Medina,Luis A. Cubano,Cornelis P. Vlaar,Suranganie Dharmawardhane +12 more
TL;DR: MBQ-167 is 10× more potent than other currently available Rac/Cdc42 inhibitors and has the potential to be developed as an anticancer drug, as well as a dual inhibitory probe for the study of Rac and Cdc42.
Proceedings ArticleDOI
Abstract A155: The Rac and PAK inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model.
Linette Castillo-Pichardo,Tessa Humphries-Bickley,Eliud Hernandez,Columba de la Parra,Luis A. Cubano,Cornelis P. Vlaar,Surangani F. Dharmawardhane Flanagan +6 more
TL;DR: The characterization of EHop-016 as a Rac inhibitor in metastatic cancer cells, and in vivo efficacy and promise for further development as targeted anti-cancer therapeutics are reported.