Showing papers by "Jose U. Scher published in 2007"
TL;DR: NO produced by activated chondrocytes in diseased cartilage may modulate disease progression in osteoarthritis and should therefore be considered a potential target for therapeutic intervention.
Abstract: The production of nitric oxide (NO) by chondrocytes is increased in human osteoarthritis. The excessive production of NO inhibits matrix synthesis and promotes its degradation. Furthermore, by reacting with oxidants such as superoxide anion, NO promotes cellular injury and renders the chondrocyte susceptible to cytokine-induced apoptosis. Thus, NO produced by activated chondrocytes in diseased cartilage may modulate disease progression in osteoarthritis and should therefore be considered a potential target for therapeutic intervention.
74 citations
TL;DR: Data indicate H. pylori effects on host epithelial MMP-1 expression via ERK, with p38 playing a potential regulatory role, indicates cagA-independent secretion in this model system.
60 citations