Showing papers in "Journal of Biological Chemistry in 2007"

TL;DR: It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.

TL;DR: A pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression is demonstrated.

TL;DR: This research presents a new probabilistic approach to cell reprograming that allows us to assess the importance of immune checkpoints in the immune response to E.coli.

TL;DR: Evidence that aquaporins can channel hydrogen peroxide (H2O2) through specific members of the aquaporin family is presented, the first molecular genetic evidence for the diffusion of H2 O2 through specificMembers of the Aquaporin Family is presented.

TL;DR: The best understood system for the transport of macromolecules between the cytoplasm and the nucleus is the classical nuclear import pathway and a bioinformatics approach is taken to analyze the likely prevalence of this system in vivo.

TL;DR: Recent advances in PGE receptor research are reviewed, including studies on knock-out mice deficient in each EP subtype have defined PGE2 actions mediated by each subtype and identified the role eachEP subtype plays in various physiological and pathophysiological responses.

TL;DR: Two-dimensional differentiation in-gel electrophoresis of tumors treated with anti-mir-21 and identified the tumor suppressor tropomyosin 1 (TPM1) as a potential mir-21 target found that down-regulation of TPM1 by mir- 21 may explain, at least in part, why suppression of mir-23 can inhibit tumor growth, further supporting the notion that mir-20 functions as an oncogene.

TL;DR: Results suggest that phosphorylation of Drp1 on Ser-585 promotes mitochondrial fission in mitotic cells, and exogenous expression of unphosphorylated mutantDrp1S585A led to reduced mitotic mitochondrial fragmentation.

TL;DR: Results indicate that the Atg12-Atg5 conjugate is a ubiquitin-protein ligase (E3)-like enzyme for Atg8-PE conjugation reaction, distinctively promoting protein-lipid conjugations.

TL;DR: It is shown that trehalose also protects cells against subsequent pro-apoptotic insults via the mitochondrial pathway, which may be relevant to the treatment of HD and related diseases, where the mutant proteins are autophagy substrates.

TL;DR: The results show that FFAs can activate CD11c+ myeloid proinflammatory cells via TLR2/4 and JNK signaling pathways, thereby promoting inflammation and subsequent cellular insulin resistance.

TL;DR: This response provides a pathologically specific mechanism for the therapeutic action of memantine, indicates a role for ROS dysregulation in ADDL-induced cognitive impairment, and supports the unifying hypothesis that ADDLs play a central role in AD pathogenesis.

TL;DR: Evidence is provided that the pro-fibrotic growth factor, TGF-β1, induces adult mouse hepatocytes to undergo phenotypic and functional changes typical of epithelial to mesenchymal transition (EMT) and that EMT is a promising therapeutic target for the attenuation of liver fibrosis.

TL;DR: It is concluded that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism and has a role in adaptive and innate immunity.

TL;DR: The results suggest that miR-221/222 can be regarded as a new family of oncogenes, directly targeting the tumor suppressor p27Kip1, and that their overexpression might be one of the factors contributing to the oncogenesis and progression of prostate carcinoma through p27kip1 down-regulation.

TL;DR: Data are consistent with a model in which PCSK9 binding to EGF-A interferes with an acid-dependent conformational change required for receptor recycling, and the LDLR is rerouted from the endosome to the lysosome where it is degraded.

TL;DR: In this paper, the authors demonstrated that AKT-activated downstream from epidermal growth factor receptor signaling, phosphorylates β-catenin at Ser552 in vitro and in vivo.

TL;DR: It is demonstrated that Klotho and βKlotho, homologous single-pass transmembrane proteins that bind to FGFRs, are required for metabolic activity of FGF23 and FGF21, respectively.

TL;DR: It is found that AMPK directly regulates mammalian FOXO3, a member of the FOXO family of Forkhead transcription factors known to promote resistance to oxidative stress, tumor suppression, and longevity, by phosphorylation by AMPK at six previously unidentified regulatory sites.

TL;DR: Evidence is provided that activation of the p90 ribosomal S6 kinases (RSKs) by serum, growth factors, tumor promoting phorbol esters, and oncogenic Ras provides an mTOR-independent pathway linking the Ras/ERK signaling cascade to the translational machinery.

TL;DR: The results indicate that oligomers are not an obligate intermediate in the fibril formation pathway and suggest that small molecule inhibitors are useful for clarifying the mechanisms underlying protein aggregation and may represent potential therapeutic agents that target fundamental disease mechanisms.

TL;DR: Protein phosphorylation at Ser637 results in clear alterations in Drp1 function and mitochondrial morphology that are likely involved in dynamic regulation of mitochondrial division in cells.

TL;DR: An increase in ROS levels in ATP-treated macrophages results in activation of a single pathway that promotes both adaptation to subsequent exposure to oxidants or inflammation, and processing and secretion of proinflammatory cytokines.

TL;DR: Findings indicate that nucleocytoplasmic shuttling is a novel regulatory mechanism of SIRT1, which may participate in differentiation and in inhibition of cell death.

TL;DR: It is argued that IL-21 serves as an autocrine factor secreted by Th17 cells that promotes or sustains Th17 lineage commitment.

TL;DR: The feasibility of using miRNAs as a therapeutic strategy to suppress oncogene expression and function is illustrated by the use of human breast cancer cell line SKBR3 as a model for ERBB2 and ERBB3 dependence.

TL;DR: The results suggest that the autoregulation between E2F1–3 and miR-20a is important for preventing an abnormal accumulation of E 2F1-3 and may play a role in the regulation of cellular proliferation and apoptosis.

TL;DR: The dual role of Brd4 in gene activation and repression illustrates how a dynamic chromatin-binding adaptor is able to recruit distinct transcriptional regulators to modulate promoter activity through cell cycle progression.

TL;DR: It is concluded that the oxidative stress that underlies physiologic organismal aging in mice may be a pivotal pathogenetic mechanism of the age-related bone loss and strength.

TL;DR: A critical role is demonstrated for PGC-1α in maintenance of normal fiber type composition and of muscle fiber integrity following exertion in skeletal muscle knock-out animals.