J
Joseph A. Buckwalter
Researcher at University of Iowa Hospitals and Clinics
Publications - 382
Citations - 32813
Joseph A. Buckwalter is an academic researcher from University of Iowa Hospitals and Clinics. The author has contributed to research in topics: Cartilage & Osteoarthritis. The author has an hindex of 87, co-authored 369 publications receiving 30885 citations. Previous affiliations of Joseph A. Buckwalter include Center for Autism and Related Disorders & University of Iowa.
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Journal ArticleDOI
Osteoarthritis: New Insights Part 1: The Disease and Its Risk Factors
David T. Felson,Reva C. Lawrence,Paul Dieppe,Rosemarie Hirsch,C. G. Helmick,Joanne M. Jordan,Raynard Kington,Nancy E Lane,Michael C. Nevitt,Yuqing Zhang,M. Sowers,Timothy E. McAlindon,Tim D. Spector,A. R. Poole,Susan Z. Yanovski,Gerard A. Ateshian,Leena Sharma,Joseph A. Buckwalter,Kenneth D. Brandt,James F. Fries +19 more
TL;DR: This article is part 1 of a two-part summary of an NIH conference, Stepping Away with OA: Prevention of Onset, Progression, and Disability of Osteoarthritis, which brought together experts in osteoarth arthritis from diverse backgrounds and provided a multidisciplinary and comprehensive summary of recent advances in the prevention.
Journal ArticleDOI
Aging and degeneration of the human intervertebral disc.
TL;DR: In this paper, the most important of these mechanisms appears to be decreasing nutrition of the central disc that allows accumulation of cell waste products and degraded matrix molecules, impairs cell nutrition, and causes a fall in pH levels that further compromises cell function and may cause cell death.
Journal Article
Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation.
TL;DR: The long-term follow-up of small series of patients has shown that the transplantation of osteochondral autologous grafts and allografts can be effective for the treatment of focal defects of articular cartilage in selected patients.
Journal Article
Articular cartilage: tissue design and chondrocyte-matrix interactions.
TL;DR: The available evidence indicates that normal matrix turnover depends on the ability of chondrocytes to detect alterations in the macromolecular composition and organization of the matrix, including the presence of degraded molecules, and to respond by synthesizing appropriate types and amounts of new molecules.
Journal ArticleDOI
Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease.
Thomas D. Brown,Richard C. Johnston,Charles L. Saltzman,J. Lawrence Marsh,Joseph A. Buckwalter +4 more
TL;DR: A population-based estimate was formulated, based on one large institution's experience in terms of its fraction of patients with OA presenting to lower-extremity adult reconstructive clinics with Oa of posttraumatic origin, that approximately 12% of the overall prevalence of symptomatic OA is attributable to posttraumatic OA of the hip, knee, or ankle.