Joseph A. Sorge

TL;DR: The discovery of a spontaneous mutation spectrum different from that of bacterial assays, coupled with the concordance of EtNU and B[a]P base mutations with the known mechanisms of activity for these mutagens, suggests that this transgenic system will be useful as a short-term, in vivo system for mutagen assessment and analysis of mechanisms leading to mutations.

TL;DR: In this paper, a method of producing libraries of genes encoding antigen-combining molecules or antibodies is described, which is useful for the detection, quantification, purification and neutralization of antigens, as well as for diagnostic, therapeutic and prophylactic purposes.

TL;DR: Two mutations, 1226 and 1448, and a new mutation (XOVR) representing cross-over between the glucocerebrosidase gene and its closely linked pseudogene, were found in 47 unrelated patients with type I Gaucher's disease.

TL;DR: A cDNA clone containing the entire human glucocerebrosidase coding region from normal cells has been isolated using lambda gt11 expression libraries, and the complete nucleotide sequence, a restriction map, and a hydropathy profile are presented.

TL;DR: A short term, in vivo mutagenesis assay has been developed utilizing a lacl target gene contained within a lambda ZAP shuttle vector which has been incorporated into transgenic mice, to allow for extrapolation of the extensive pool of in vitro data to whole animals, and provide insight into the tissue specific effects of mutagenic compounds.